Raissa Aronica

Neisseria lactamica meningitis as the initial presentation of a rhino–cerebrospinal fluid fistula in an adult with remote cranial trauma

Sara Figliomeni, Claret Osimiri, Rabiyya Ashurova, Irene Corbo et autres

Background Neisseria lactamica is a commensal of the upper respiratory tract in children and is rarely isolated in adults. Its genome shares approximately 60% homology with Neisseria meningitidis but lacks the virulence genomic islands essential for blood–brain barrier invasion. Meningitis due to …

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GRAd-COV2 vaccine provides potent and durable humoral and cellular immunity to SARS-CoV-2 in randomized placebo-controlled phase 2 trial

Stefania Capone, Francesco Maria Fusco, Stefano Milleri, Silvio Borrè et autres

The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and heterologous immunization approaches implemented worldwide for booster doses call for diversified vaccine portfolios. GRAd-COV2 is a gorilla adenovirus-based COVID-19 vaccine candidate encoding prefusion-stabilized spike. The safety and immunogenicity of GRAd-COV2 is …

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Real-life use of remdesivir-containing regimens in COVID-19: a retrospective case-control study

Francesco Cogliati Dezza, Alessandra Oliva, Vera Mauro, Francesco Eugenio Romani et autres

Background: and efficacy in animal models of COVID-19; nevertheless, clinical trials and real-life reports have shown conflicting data on its effectiveness. Aims of the study were to evaluate the impact of remdesivir on I) Intensive Care Unit (ICU) admission, II) need for …

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SARS-CoV-2 Among Migrants Recently Arrived in Europe From Low- and Middle-Income Countries: Containment Strategies and Special Features of Management in Reception Centers

Silvia Fabris, Gabriella d’Ettorre, Ornella Spagnolello, Alessandro Russo et autres

Despite the "migrants and COVID-19" topic has been neglected since felt marginal concerning other aspects of the SARS-CoV-2 pandemic, it represents a relevant public health issue in the European countries. This report describes COVID-19 containment strategies adopted in a large Italian reception …

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Comparison of Thrombotic Events and Mortality in Patients with Community-Acquired Pneumonia and COVID-19: A Multicenter Observational Study

Roberto Cangemi, Camilla Calvieri, Marco Falcone, Francesco Cipollone et autres

Abstract Background It is still unclear if patients with community-acquired pneumonia (CAP) and coronavirus disease 2019 (COVID-19) have different rate, typology, and impact of thrombosis on survival. Methods In this multicenter observational cohort study, 1,138 patients, hospitalized for CAP (n = 559) …

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Role of Serum E-Selectin as a Biomarker of Infection Severity in Coronavirus Disease 2019

Alessandra Oliva, Emanuele Rando, Dania Al Ismail, Massimiliano De Angelis et autres

Introduction: E-selectin is a recognized marker of endothelial activation; however, its place in Coronavirus Disease 2019 (COVID-19) has not been fully explored. Aims of the study are to compare sE-selectin values among the Intensive Care Unit (ICU)-admitted and non-admitted, survived and non-survived …

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Candida fracture-related infection: a systematic review

Daniele De Meo, Gianluca Cera, Giancarlo Ceccarelli, Valerio Castagna et autres

Abstract. Background: The aim of this study is to summarize and improve knowledge regarding a Candida fracture-related infection (CFRI) through a systematic review on the topic, accompanied by a case report. Methods: A systematic review and meta-analysis based on PRISMA statement were …

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Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19

Alessandra Oliva, Maria Claudia Miele, Federica Di Timoteo, Massimiliano De Angelis et autres

Microbial translocation (MT) and intestinal damage (ID) are poorly explored in COVID-19. Aims were to assess whether alteration of gut permeability and cell integrity characterize COVID-19 patients, whether it is more pronounced in severe infections and whether it influences the development of …

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Arterial and venous thrombosis in coronavirus 2019 disease (Covid-19): relationship with mortality

Francesco Violi, Giancarlo Ceccarelli, Roberto Cangemi, Francesco Cipollone et autres

BACKGROUND: Patients with coronavirus disease 2019 (Covid-19) may experience venous thrombosis while data regarding arterial thrombosis are sparse. METHODS: Prospective multicenter study in 5 hospitals including 373 patients with Covid-19-related pneumonia. Demographic data, laboratory findings including coagulation tests and comorbidities were reported. …

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Real-life experience in the use of ceftobiprole for the treatment of nosocomial pneumonia: a case series

Alessandra Oliva, G. Savellon, Francesca Cancelli, Serena Valeri et autres

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Cardiometabolic multimorbidity is associated with a worse Covid-19 prognosis than individual cardiometabolic risk factors: a multicentre retrospective study (CoViDiab II)

Ernesto Maddaloni, Luca D’Onofrio, Francesco Alessandri, Carmen Mignogna et autres

Abstract Background Cardiometabolic disorders may worsen Covid-19 outcomes. We investigated features and Covid-19 outcomes for patients with or without diabetes, and with or without cardiometabolic multimorbidity. Methods We collected and compared data retrospectively from patients hospitalized for Covid-19 with and without diabetes, …

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