Myron K. Evans

Preclinical efficacy of combinatorial B7-H3 CAR T cells and ONC206 against diffuse intrinsic pontine glioma.

Andrea Timpanaro, Edward Z. Song, Ryma Toumi, Leonel Elena-Sanchez et autres

Background Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric brain tumor affecting over 300 children annually in the United States. Chimeric antigen receptor (CAR) T cells are a targeted immune effector cell therapy with substantial clinical benefit against hematologic cancers. Against …

Preclinical efficacy of combinatorial B7-H3 CAR T cells and ONC206 against diffuse intrinsic pontine glioma

Andrea Timpanaro, Edward Z. Song, Ryma Toumi, Leonel Elena-Sanchez et autres

BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric brain tumor affecting over 300 children annually in the United States. Chimeric antigen receptor (CAR) T cells are a targeted immune effector cell therapy with substantial clinical benefit against hematologic cancers. Against …

us, au (code pays fourni par la source)

Engineered CXCR3-A expression enhances B7-H3-targeting CAR T cell migration and efficacy against diffuse intrinsic pontine glioma

Edward Z. Song, Andrea Timpanaro, Michael Meechan, Leonel Elena-Sanchez et autres

Diffuse intrinsic pontine glioma (DIPG) is a fatal brainstem tumor desperately in need of better treatments. Chimeric antigen receptor (CAR) T cell therapies for DIPG have demonstrated clinical tolerability and bioactivity, but not universal benefit. A major obstacle is insufficient CAR T …

us, au (code pays fourni par la source)

Non-cell-autonomous tumor promotion in DICER1 cancer predisposition

Randolph K. Larsen, Jason A. Hanna, Hongjian Jin, Kristin B. Reed et autres

DICER1-related tumors are characterized by germline loss-of-function mutations in one DICER1 allele ( DICER1 +/− ) and a somatic “second hit” mutation in the remaining DICER1 allele. Whether the germline DICER1 +/− mutation participates in tumorigenesis is unknown. We show that germline …

us (code pays fourni par la source)

Transdifferentiation of endothelial progenitor cells into rhabdomyosarcoma defined by hedgehog signaling competence

Katherine E. Gadek, Catherine J. Drummond, Hongjian Jin, Matthew R. Garcia et autres

Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma resembling developing skeletal muscle, but tumors are found in sites devoid of skeletal muscle, suggesting a non-myogenic cell of origin. We previously described an endothelial progenitor cell-derived model of RMS by activating a conditional, …

us (code pays fourni par la source)

Preclinical efficacy of combinatorial B7-H3 CAR T cells and ONC206 against diffuse intrinsic pontine glioma

Andrea Timpanaro, Edward Z. Song, Ryma Toumi, Leonel Elena-Sanchez et autres

ABSTRACT Background Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric brain tumor affecting over 300 children annually in the United States. Chimeric antigen receptor (CAR) T cells are a targeted immune effector cell therapy with substantial clinical benefit against hematologic cancers. …

us, au (code pays fourni par la source)

MDB-34. CDK8 inhibition enhances radiotherapy efficacy in MYC -amplified medullloblastoma

Isabella Terrones, Hawa Jagana, Matthew Hathaway, John Hemenway et autres

Abstract Medulloblastoma (MB) is the most common malignant pediatric brain tumor with Group 3 (G3) tumors having the lowest overall survival rate. Using the Pediatric Cancer Dependency Map to screen for therapeutic dependencies, we previously identified cyclin-dependent kinase 8 (CDK8) as the …

us (code pays fourni par la source)

MDB-35. Elucidating YBX1 as a dependency in pediatric medulloblastoma

Stephen V. Carney, John Hemenway, Kate E. Gadek, Christian Bonatto Paese et autres

Abstract Current standard of care treatment for medulloblastoma (MB) consists of maximal resection surgery followed by craniospinal irradiation and chemotherapy, with survivors experiencing diminished quality of life from intensive treatment regimens. The identification of novel targets is an unmet need and critical …

us (code pays fourni par la source)

Conference Report: Cerebellar Development and Disease at Single-Cell Resolution

Lena M. Kutscher, Davide Aprile, Nermin Sumru Bayin, Esther B. E. Becker et autres

Acknowledgements: We thank all participants for their contributions. We thank the sponsors for the meeting for financial and logistical support.

de, it, gb, fr, us, ca (code pays fourni par la source)

Abstract 6400: Preclinical efficacy of combinatorial B7-H3 CAR T cell and ONC206 treatment in DIPG/DMG

Andrea Timpanaro, Edward Z. Song, Matthew C. Biery, Ryma Toumi et autres

B7-H3 CAR T cell treatment in combination with ONC206 aims to assess benefit and significant extension of survival in orthotopic DIPG mouse models. BACKGROUND. Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric tumor arising in the pons and affecting over 300 …

us, au (code pays fourni par la source)

Engineered CXCR3-A expression enhances the trafficking and efficacy of intracerebroventricularly delivered B7-H3-targeting CAR T cells against diffuse intrinsic pontine glioma

Nicholas Alexander Vitanza, Edward Z. Song, Andrea Timpanaro, Michael Meechan et autres

us (code pays fourni par la source)

Abstract PR010: DICER1 cancer predisposition tumor promotion mediated non-cell autonomously via neutrophils and NETosis

Randolph K. Larsen, Jason A. Hanna, Hongjian Jin, Darden W. Kimbrough et autres

Abstract DICER1 cancer predisposition syndrome is a heritable condition where affected patients have increased risk of neoplasms including fusion-negative rhabdomyosarcoma (FN-RMS). The syndrome is defined by germline heterozygous loss of function mutations in DICER1, but it remains unclear exactly how these mutations …

us (code pays fourni par la source)