Serena Cecchetti

Induction of aneuploidy by the metal-chelating agent neodecanoid acid in mammalian cells in vitro

Francesca Marcon, Giorgia Maria Varalda, Carmen Del Franco, Laura Torrieri Di Tullio et autres

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Integrating Artificial Intelligence and Assistive Technologies in Higher Technical Education: The Role of Spoke 4 at Rome Technopole

Giuseppe Esposito, Massimo Sanchez, Federica Fratini, Egidio Iorio et autres

Higher technical and professional education is increasingly discussed in relation to workforce readiness, innovation, and societal inclusion. In Italy, the PNRR-funded Rome Technopole operates as a multi-institutional ecosystem in which universities, research organizations, industry, and public bodies interact through a Hub & …

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Muscle ultrasonography in costello syndrome: unveiling new clinical insights of a complex muscular phenotype

Chiara Leoni, Germana Viscogliosi, Deborah Pajalunga, Valentina Trevisan et autres

BACKGROUND: Costello syndrome (CS) is a rare genetic disorder within the spectrum of RASopathies, caused by activating mutations in the HRAS gene, leading to constitutive dysregulation of the RAS/MAPK signalling pathway. Among its multisystemic manifestations, a distinctive musculoskeletal involvement is frequently observed …

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Muscle ultrasonography in costello syndrome: unveiling new clinical insights of a complex muscular phenotype

Chiara Leoni, Germana Viscogliosi, Deborah Pajalunga, Valentina Trevisan et autres

Abstract Background Costello syndrome (CS) is a rare genetic disorder within the spectrum of RASopathies, caused by activating mutations in the HRAS gene, leading to constitutive dysregulation of the RAS/MAPK signalling pathway. Among its multisystemic manifestations, a distinctive musculoskeletal involvement is frequently …

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Additional file 1 of Muscle ultrasonography in costello syndrome: unveiling new clinical insights of a complex muscular phenotype

Chiara Leoni, Germana Viscogliosi, Deborah Pajalunga, Valentina Trevisan et autres

Supplementary Material 1: Fasting biochemical parameters at the time of ultrasonography evaluationThe table summarizes the distribution of key biochemical markers in the study cohort, including lower and higher recorded values, median, and reference ranges. Parameters assessed included fasting glycemia, triglycerides (TAGs), total …

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Muscle ultrasonography in costello syndrome: unveiling new clinical insights of a complex muscular phenotype

Chiara Leoni, Germana Viscogliosi, Deborah Pajalunga, Valentina Trevisan et autres

Abstract Background Costello syndrome (CS) is a rare genetic disorder within the spectrum of RASopathies, caused by activating mutations in the HRAS gene, leading to constitutive dysregulation of the RAS/MAPK signalling pathway. Among its multisystemic manifestations, a distinctive musculoskeletal involvement is frequently …

it, jp (code pays fourni par la source)

Additional file 1 of Muscle ultrasonography in costello syndrome: unveiling new clinical insights of a complex muscular phenotype

Chiara Leoni, Germana Viscogliosi, Deborah Pajalunga, Valentina Trevisan et autres

Supplementary Material 1: Fasting biochemical parameters at the time of ultrasonography evaluationThe table summarizes the distribution of key biochemical markers in the study cohort, including lower and higher recorded values, median, and reference ranges. Parameters assessed included fasting glycemia, triglycerides (TAGs), total …

it, jp (code pays fourni par la source)

Additional file 4 of Muscle ultrasonography in costello syndrome: unveiling new clinical insights of a complex muscular phenotype

Chiara Leoni, Germana Viscogliosi, Deborah Pajalunga, Valentina Trevisan et autres

Supplementary Material 3: Lipid droplets detection in proliferating muscle cells stably expressing WT and mutants HRAS Representative images showing an increased amount of lipid droplets in proliferating myoblasts expressing HRAS mutants (G12S and G13C) compared to cells expressing WT HRAS and control …

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Additional file 4 of Muscle ultrasonography in costello syndrome: unveiling new clinical insights of a complex muscular phenotype

Chiara Leoni, Germana Viscogliosi, Deborah Pajalunga, Valentina Trevisan et autres

Supplementary Material 3: Lipid droplets detection in proliferating muscle cells stably expressing WT and mutants HRAS Representative images showing an increased amount of lipid droplets in proliferating myoblasts expressing HRAS mutants (G12S and G13C) compared to cells expressing WT HRAS and control …

it, jp (code pays fourni par la source)

Additional file 2 of Muscle ultrasonography in costello syndrome: unveiling new clinical insights of a complex muscular phenotype

Chiara Leoni, Germana Viscogliosi, Deborah Pajalunga, Valentina Trevisan et autres

Supplementary Material 2: Daily macronutrients kilocaloric intake according to reference range The table shows the distribution of participants with appropriate, below-range, or above-range daily caloric intake for carbohydrates, lipids, and proteins

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Additional file 2 of Muscle ultrasonography in costello syndrome: unveiling new clinical insights of a complex muscular phenotype

Chiara Leoni, Germana Viscogliosi, Deborah Pajalunga, Valentina Trevisan et autres

Supplementary Material 2: Daily macronutrients kilocaloric intake according to reference range The table shows the distribution of participants with appropriate, below-range, or above-range daily caloric intake for carbohydrates, lipids, and proteins

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Abstract 1758: Targeted DNA damage through SSTR2: Preclinical development of a novel peptide-drug conjugate for neuroendocrine tumors

Gianluca Fossati, Daniela Modena, Luca Menin, Michela Bottani et autres

Abstract Targeted induction of DNA damage in tumor cells offers a promising strategy to efficiently kill cancer cells while sparing healthy tissues. Precise tumor targeting can be achieved by the exploitation of the differential expression of specific molecular targets on the surface …

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