2026
conference-abstract
OpenAlex
Beatrice Wendler Awasthi, Nicole A. Lester, Deniz G. Olgun, Yi Cui et autres
Abstract Pancreatic adenocarcinoma (PDAC) remains one of the leading causes of cancer mortality. It has become increasingly clear that the spatial architecture of tumors can drastically influence treatment response and prognosis. Advances in large-scale spatial profiling have enabled detailed in situ mapping …
us, au
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Rachel Liu, Joe Phan, Rustem Khafizov, Kimberly Young et autres
Abstract MicroRNAs (miRNAs) are small, conserved noncoding RNAs that play an important role in cancer mechanisms and translational research, acting as oncogenes (e.g., miR-21), tumor suppressors (e.g., miR-200 family), and immune modulators (e.g., miR-155). However, miRNAs and their spatial and temporal implications, …
us
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Terence C. Theisen, Alexa E Lasley, Giang T. Ong, Megan Vandenberg et autres
Abstract The tumor microenvironment (TME) is a heterogeneous landscape where immune cells interact with malignant cells to influence cancer progression and therapeutic response, but to date, dissecting the spatial proteomic signature of the TME has been limited by plex and resolution. Here …
us
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Evelyn Metzger, Patrick Danaher, Nicole Ortogero, Sayani Bhattacharjee et autres
Abstract The potential of whole-transcriptome spatial analysis to answer complex biological questions is often hindered by the sheer weight of its computational and analytical demands. As the number of cells, samples, and plex increases these computational challenges are compounded resulting in bottlenecks …
us, au
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Daniel Jiménez-Sánchez, Matthew H. Ingalls, Sanghamithra Korukonda, Brian J. Lane et autres
Abstract Introduction: FOXP3+ regulatory T cells (Tregs) maintain immune tolerance, and their dysfunction contributes to autoimmunity, chronic inflammation, and cancer. Treg heterogeneity is well documented in ulcerative colitis, where dysregulated Tregs can promote colon cancer. Treg heterogeneity is often defined by transcriptional …
us, ph
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Brian Filanoski, Lori Hamanishi, Giang T. Ong, Terence C. Theisen et autres
Abstract Multiomic approaches combining transcriptomic and proteomic data are critical for understanding complex biological systems in oncology. The nCounter® platform enables simultaneous quantification of RNA and protein targets from the same sample, reducing variability and maximizing biological insight. This innovation builds upon …
us
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Giang T. Ong, Terence C. Theisen, Brian Filanoski, Lori Hamanishi et autres
Abstract Expanded development on the nCounter® Analysis System now enables simultaneous quantification of over 500 proteins and up to 800 transcripts from a single FFPE tissue sample. With the introduction of two high-plex protein panels used in combination with any prebuilt nCounter® …
us
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Margaret L. Hoang, Rachel Liu, Dan McGuire, Ashley Heck et autres
Abstract Immune cell dynamics shape tumor responses to therapy. Peripheral blood mononuclear cells (PBMCs) offer a systemic view of adaptive immunity, yet conventional immune sequencing lacks the spatial resolution to contextualize these findings within tissue architecture. High resolution spatial mapping of tumor-infiltrating …
us
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Yi Cui, Claire Williams, Chia-Ying Lee, Chi Q. Phan et autres
Abstract Glioblastoma (GBM) is a highly heterogeneous and aggressive brain tumor with limited therapeutic success, underscoring the need for advanced approaches to decode its complex molecular landscape. Here, we employed the CosMx® Spatial Molecular Imager to perform same-cell spatial multiomics profiling on …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Peter Wang, Nicole A. Lester, Ella Perrault, Jennifer Su et autres
Nerves are an integral component of the tumor microenvironment, contributing to cancer progression, metastasis, morbidity, and mortality. In pancreatic ductal adenocarcinoma (PDAC), worse clinical outcomes are associated with perineural invasion (PNI), a process by which cancer cells surround and invade nerves. Here, …
us, gb, kr
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Rosane M. B. Teles, Chaouki Benabdessalem, Jonathan Perrie, Cenfu Wei et autres
Abstract Pulmonary tuberculosis (TB) exhibits marked spatial heterogeneity, with alveolar pneumonia and organized granulomas frequently coexisting within the same lung. While granulomas have long dominated conceptual models of TB pathogenesis, the immune programs operating within alveolar TB pneumonia in humans remain incompletely …
us, Tunisie, Afrique du Sud
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Gege Gui, Molly A. Bingham, Jeremy Herzog, Abigail Wong-Rolle et autres
Given the graft-versus-leukemia effect observed with allogeneic hematopoietic stem cell transplantation in refractory or relapsed acute myeloid leukemia (AML), immunotherapies have been explored in nontransplant settings. We applied a multiomic approach to examine bone marrow interactions in patients with AML treated with …
us
(code pays fourni par la source)