Holly Marfani

Clonal Candida auris and ESKAPE pathogens on the skin of residents of nursing homes

Diana M. Proctor, Sarah E. Sansom, Clay Deming, Sean Conlan et autres

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Integrated genomic and functional analyses of human skin–associated Staphylococcus reveal extensive inter- and intra-species diversity

Payal Joglekar, Sean Conlan, Shih-Queen Lee-Lin, Clay Deming et autres

Human skin is stably colonized by a distinct microbiota that functions together with epidermal cells to maintain a protective physical barrier. Staphylococcus , a prominent genus of the skin microbiota, participates in colonization resistance, tissue repair, and host immune regulation in strain-specific …

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Genomic characterization of the C. tuberculostearicum species complex, a prominent member of the human skin microbiome

Nashwa Ahmed, Payal Joglekar, Clayton Deming, Katherine P. Lemon et autres

ABSTRACT Corynebacterium is a predominant genus in the skin microbiome, yet its genetic diversity on the skin is incompletely characterized and underrepresented in public databases. We investigated the distribution of Corynebacterium species on the skin and expanded the existing genome reference catalog. …

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A genome catalog of the early-life human skin microbiome

Zeyang Shen, Lukian Robert, Milan Stolpman, You Che et autres

BACKGROUND: Metagenome-assembled genomes have greatly expanded the reference genomes for skin microbiome. However, the current reference genomes are largely based on samples from adults in North America and lack representation from infants and individuals from other continents. RESULTS: Here we use deep …

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Expanded microbiome niches of RAG-deficient patients

Ryan A. Blaustein, Zeyang Shen, Sara Saheb Kashaf, Shih-Queen Lee-Lin et autres

The complex interplay between microbiota and immunity is important to human health. To explore how altered adaptive immunity influences the microbiome, we characterize skin, nares, and gut microbiota of patients with recombination-activating gene (RAG) deficiency-a rare genetically defined inborn error of immunity …

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Roving methyltransferases generate a mosaic epigenetic landscape and influence evolution in Bacteroides fragilis group

Michael J. Tisza, Derek D. N. Smith, Andrew E. Clark, Jung-Ho Youn et autres

Three types of DNA methyl modifications have been detected in bacterial genomes, and mechanistic studies have demonstrated roles for DNA methylation in physiological functions ranging from phage defense to transcriptional control of virulence and host-pathogen interactions. Despite the ubiquity of methyltransferases and …

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Integrating cultivation and metagenomics for a multi-kingdom view of skin microbiome diversity and functions

Sara Saheb Kashaf, Diana M. Proctor, Clay Deming, Paul Saary et autres

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Integrated genomic, epidemiologic investigation of Candida auris skin colonization in a skilled nursing facility

Diana M. Proctor, Thelma Dangana, D. Joseph Sexton, Christine Fukuda et autres

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