Lilei Yu

Morphology-Engineered Gold Nanostars for Activatable NIR-II Imaging of Intracellular miR-21 with Deep Tissue Capability

Lei Zhang, Yuqin Liao, Lvyun Zhu, Yingying Li et autres

Near-infrared II (NIR-II, 1000-1700 nm) fluorescence imaging enables deep-tissue analysis, but conventional "always-on" probes suffer from high background that compromises the signal-to-background ratio for low-abundance targets. Activatable probe strategies could mitigate this issue, yet most existing designs rely on fluorescence resonance energy …

cn, us, tr (code pays fourni par la source)

Metal–Organic Framework as a Bioorthogonal Catalyst for Gene Editing

Z H Chen, Xingyu Liu, Wanyue Sang, Li Li et autres

We report the use of reticular design to construct metal-organic frameworks (MOFs) with molecularly defined catalytic pores for bioorthogonal RNA manipulation in living cells. A library of crystalline MOFs with systematically varied Cu cluster geometries, pore dimensions, and chemical environments was assembled …

cn (code pays fourni par la source)

Erratum to ‘Neuroimmune modulation mediated by IL-6: A potential target for the treatment of ischemia-induced ventricular arrhythmias’ [Heart Rhythm 21/5 (2024) 610-619]

Cheng Peng, Yanmei Lu, Rui Li, L F Zhang et autres

cn (code pays fourni par la source)

Bovine Serum Albumin Crosslinked Hydrogels with Enhanced Mechanical Properties for Skin Bioelectronics

Yuecong Luo, Kaixiang Long, Minzhang Chen, Chenxi Hu et autres

The applications of hydrogel in the field of skin bioelectronics are rapidly expanding, and the development of hydrogels with both superior mechanical properties and strong adhesion is critical for facilitating their clinical translation. Here, a protein crosslinking strategy is reported, in which …

cn (code pays fourni par la source)

A transistor-based point-of-care assay with lipid-capped sensory interface for clinical profiling of cardiovascular diseases

Duo Chen, Nan Song, Yun Zhang, Fuding Guo et autres

Point-of-care (POC) testing for electrical detection of cardiovascular disease (CVD) can enable effective screening and surveillance. However, the complexity and diversity of serum samples interfere with the transduction of electrical signals, limiting the sensitivity and accuracy of the biochemical assay. Here, we …

cn (code pays fourni par la source)

Effect of a Computer-Aided Device for Detecting Gastric Neoplasms: A Multicenter, Randomized Controlled Trial

Zehua Dong, Lianlian Wu, Hongliu Du, Xiao Tao et autres

BACKGROUND & AIMS: Evidence about the effect of artificial intelligence (AI) on upper endoscopy in multicenter, randomized controlled trials is lacking. We aimed to explore whether AI can enhance gastric neoplasm detection. METHODS: Participants from 24 hospitals in China from December 21, …

cn (code pays fourni par la source)

Advancing coronary artery disease risk stratification: integrating hyperspectral imaging with machine learning for precision cardiology

Xinyu Liu, Tianyou Xu, Wanyue Sang, Zeyan Li et autres

Coronary artery disease (CAD) remains one of the leading causes of death worldwide, making precise risk stratification essential for personalized medicine. Hyperspectral imaging (HSI) has emerged as a novel noninvasive medical imaging technology with significant potential in CAD detection and risk stratification. …

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Adenosine signaling in the habenula: a depression-myocardial infarction nexus

Lei Zhang, Mengge Chu, Cailing Ji, Yawen Zhang et autres

cn (code pays fourni par la source)

Passive Monitoring to Active Regulation: Closed-Loop Piezoelectric Theranostic Platform Enabling On-Demand Vagus Stimulation for Terminating Inappropriate Sinus Tachycardia

Guangyan Liu, Tianyou Xu, Liping Zhou, Zhongkun Wang et autres

Inappropriate sinus tachycardia (IST), characterized by unexplained acceleration of sinus rhythm, poses significant diagnostic and therapeutic challenges due to its paroxysmal and limited treatment options. This study proposes a closed-loop theranostic platform (TP-IST) based on an implantable piezoelectric fiber patch (iPFP) for …

cn (code pays fourni par la source)

Prognostic impact of guideline-directed medical therapy after functionally complete revascularisation in patients with obstructive coronary artery diseases

Yingyang Geng, Changdong Guan, Yao Jiang, Weixian Yang et autres

OBJECTIVE: Functional complete revascularisation (FCR) has been proven to be associated with superior prognosis following percutaneous coronary intervention. Whether guideline-directed medical therapy (GDMT) still impacts clinical outcomes in patients who have achieved FCR requires further evaluation. METHODS: The study population was drawn …

cn, jp (code pays fourni par la source)

Evaluation of the effectiveness of a digital-intelligent-system-based implementation strategy in improving the quality of prehospital medical care: rationale and design of a stepped-wedge cluster randomized controlled trial

Lang Wang, Yali Hu, Bowen Hou, Ying Cui et autres

BACKGROUND: Currently, prehospital emergency medical care procedures and quality vary among different medical institutions, and there is no effective implementation strategy for improving medical quality. Acute cardiovascular disease imposes major burdens to all involved parties and is associated with high morbidity and …

cn (code pays fourni par la source)

Ultra-stretchable, adhesive and photothermal multifunctional hydrogel for renal denervation to treat hypertension

Heng Lin, Haosong Xi, Hengyang Liu, Ze Qiang Zhao et autres

Hypertension is a major risk factors for stroke, cardiovascular diseases, and chronic kidney diseases. Although taking antihypertension drugs improves the prognosis of hypertensive patients to a certain extent, there are still lots of refractory hypertension and non-adherent patients. Therefore, it is imperative …

cn (code pays fourni par la source)