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Nadeen Anabtawi, Thomas Drabison, Alexander F. Ham, Mike Boeckman et autres
Tissue distribution of radiolabeled decitabine following oral administration.
Nadeen Anabtawi, Thomas Drabison, Alexander F. Ham, Mike Boeckman et autres
Supplementary Methods
Nadeen Anabtawi, Thomas Drabison, Alexander F. Ham, Mike Boeckman et autres
Abstract Decitabine is a DNA hypomethylating agent used in the treatment of patients with myelodysplastic syndromes and acute myeloid leukemia that is administered intravenously because of its poor oral bioavailability. An oral medication containing decitabine and cedazuridine has been approved for human …
Nadeen Anabtawi, Thomas Drabison, Alexander F. Ham, Mike Boeckman et autres
Dose-dependent effects of cedazuridine on oral decitabine pharmacokinetics.
Nadeen Anabtawi, Thomas Drabison, Alexander F. Ham, Mike Boeckman et autres
Effect of cedazuridine on intravenous decitabine pharmacokinetics in mice.
Nadeen Anabtawi, Thomas Drabison, Alexander F. Ham, Mike Boeckman et autres
CNT1 deletion reduces systemic decitabine exposure and increases renal loss. A, Schematic of the uptake assay design using HEK293 cells stably overexpressing CNT1. [3H]-decitabine uptake was measured to assess CNT1-mediated transport. B, [3H]-decitabine uptake in CNT1-overexpressing cells (CNT1 OE) compared with vector …
Nadeen Anabtawi, Thomas Drabison, Alexander F. Ham, Mike Boeckman et autres
Cedazuridine restores oral decitabine bioavailability to intravenous-equivalent levels. A, Plasma concentration–time profiles of decitabine following intravenous or oral (10 mg/kg) administration in WT mice, with or without oral co-administration of oral cedazuridine (3 mg/kg). Cedazuridine markedly increased oral decitabine exposure, restoring systemic …
Nadeen Anabtawi, Thomas Drabison, Alexander F. Ham, Mike Boeckman et autres
Effect of CNT1 deletion on oral decitabine pharmacokinetics.
Nadeen Anabtawi, Thomas Drabison, Alexander F. Ham, Mike Boeckman et autres
Cedazuridine increases urinary excretion of decitabine independent of CDA. A, Schematic of experimental design. Mice received oral decitabine (10 mg/kg) with or without oral cedazuridine (3 mg/kg) and were housed in metabolic cages for urine and feces collection. At study endpoint, tissues …
Nadeen Anabtawi, Thomas Drabison, Alexander F. Ham, Mike Boeckman et autres
Plasma concentration–time profiles of decitabine following intravenous or oral administration in wild-type (WT) mice.
Nadeen Anabtawi, Thomas Drabison, Alexander F. Ham, Mike Boeckman et autres
CDA deletion greatly increases oral decitabine exposure. A, Plasma concentration–time profiles of decitabine following intravenous or oral (10 mg/kg) administration in WT mice. Oral bioavailability of decitabine in WT animals is markedly reduced compared with intravenous dosing. B, Plasma concentration–time profiles of …
Nadeen Anabtawi, Thomas Drabison, Alexander F. Ham, Mike Boeckman et autres
Cedazuridine potently inhibits cytidine deaminase (CDA) activity in a cell-free assay.
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