Junichi Sugawara

Effect of healthy lifestyle on renal dysfunction risk: interactions with genetic risk

Masato Takase, Naoki Nakaya, Mana Kogure, Rieko Hatanaka et autres

ABSTRACT Background Whether adherence to a healthy lifestyle can mitigate genetic risk for renal dysfunction remains unclear. Methods This prospective cohort study included 12 680 adults aged ≥20 years, free from chronic kidney disease at baseline, enrolled in the Tohoku Medical Megabank …

jp (code pays fourni par la source)

Cohort Profile Update: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) 2023 update

Taku Obara, Mami Ishikuro, Aoi Noda, Keiko Murakami et autres

The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) included pregnant women, children, fathers, grandparents, and other family members across Japan between 2013 and 2017. The aims of the study were to assess health status following the …

jp (code pays fourni par la source)

Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study

Masato Takase, Naoki Nakaya, Mana Kogure, Rieko Hatanaka et autres

BACKGROUND: No previous studies have explored metabolites associated with both genetic predispositions to type 2 diabetes (T2DM) and T2DM onset. Therefore, we aimed to explore metabolic profiles using genetic risk to identify pathways for tailored T2DM prevention strategies. METHODS: This prospective community-based …

jp (code pays fourni par la source)

Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension

Masato Takase, Takumi Hirata, Naoki Nakaya, Mana Kogure et autres

Family history of hypertension may reflect genetic and lifestyle factors. Genetic risk can be assessed using polygenic risk score (PRS); however, whether PRS can stratify hypertension risk when combined with family history and lifestyle information is unclear. This prospective cohort study included …

jp (code pays fourni par la source)

Development of AI Models for Early Prediction of Preterm Birth

Satoshi Mizuno, Satoshi Nagaie, Gen Tamiya, Shinichi Kuriyama et autres

Preterm birth is one of the most important neonatal complications. In this study, we aimed to establish an artificial intelligence model for early prediction of preterm birth. Based on genetic and lifestyle data from over 20,000 neonates, we developed high-performed early prediction …

jp (code pays fourni par la source)

Household income modifies the association between social capital and gestational diabetes mellitus in Japan: Results from TMM BirThree Cohort Study

Koichi Sakakibara, Tomoki Kawahara, Nobutoshi Nawa, Keiko Murakami et autres

INTRODUCTION: While social capital can prevent diabetes, these benefits can be heterogeneous with respect to socioeconomic status. We investigated the association between social capital and gestational diabetes mellitus (GDM) while examining effect modification by household income. MATERIALS AND METHODS: We conducted a …

us, jp (code pays fourni par la source)

Preeclampsia prediction with maternal and paternal polygenic risk scores: the TMM BirThree Cohort Study

Hisashi Ohseto, Mami Ishikuro, Taku Obara, Akira Narita et autres

Genomic information from pregnant women and the paternal parent of their fetuses may provide effective biomarkers for preeclampsia (PE). This study investigated the association of parental polygenic risk scores (PRSs) for blood pressure (BP) and PE with PE onset and evaluated predictive …

jp (code pays fourni par la source)

Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn, Motomichi Matsuzaki, Akira Narita, Takamitsu Funayama et autres

Runs of homozygosity (ROHs) are widely observed across the genomes of various species and have been reported to be associated with many traits and common diseases, as well as rare recessive diseases, in human populations. Although single nucleotide polymorphism (SNP) array data …

jp (code pays fourni par la source)

Has the impact of cigarette smoking on mortality been underestimated by overlooking second-hand smoke? Tohoku medical megabank community-based cohort study

Masato Takase, Naoki Nakaya, Kozo Tanno, Mana Kogure et autres

Objectives: Previous studies have assessed the impact of active smoking on mortality using the population-attributable fraction (PAF). However, these studies have not included second-hand smoking (SHS), potentially underestimating smoking's impact. We compared the PAF from active smoking alone with the PAF, including …

jp (code pays fourni par la source)

Genetic effects on gestational diabetes mellitus and their interactions with environmental factors among Japanese women

Tomoki Kawahara, Nobutoshi Nawa, Keiko Murakami, Toshihiro Tanaka et autres

jp, us (code pays fourni par la source)

Exploring the association between human breast milk lipids and early adiposity rebound in children: A case-control study

Kento Sawane, Ippei Takahashi, Mami Ishikuro, Hiroko Takumi et autres

OBJECTIVES: Adiposity rebound (AR) corresponds to the start of the second rise in the body mass index curve during infant growth. Early AR (before age 5) confers increased risk of adiposity and metabolic disorders but is less likely to occur in breastfed …

jp (code pays fourni par la source)

Association Between Human Milk Oligosaccharides and Early Adiposity Rebound in Children: A Case–Control Study of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Kento Sawane, Ippei Takahashi, Mami Ishikuro, Hiroko Takumi et autres

jp (code pays fourni par la source)