Accès ouvert
2026
article
OpenAlex
Isabelle Rydén, Dongni Buvarp, Alice Neimantaite, Louise Carstam et autres
Abstract Background Cognitive impairment, fatigue, and reduced health-related quality of life (HRQoL) are common in patients with IDH-mutant gliomas. However, it remains unclear which cognitive domains are most relevant for global HRQoL, how fatigue relates to these associations, and whether this differs …
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Accès ouvert
2026
article
OpenAlex
Pernilla Ståhl, Ingela Henoch, Ramona Schenell, Bertil Rydenhag et autres
PURPOSE: The aim of this review was to systematically map support interventions for patients with primary high-grade brain tumours and their relatives. METHODS: Searches were conducted in electronic databases and reference lists of included articles. Articles published between 2013 and 2025 were …
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Accès ouvert
2025
review
OpenAlex
Tora Dunås, Sophia M. Leiss, Alba Corell, Thomas Skoglund et autres
INTRODUCTION: Cognitive outcomes following brain insult are shaped by a range of factors, including genetic predispositions. Emerging evidence indicates that specific genetic variants may affect the susceptibility to cognitive impairment in individual patients. In this systematic review we summarize the evidence for …
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Accès ouvert
2025
article
OpenAlex
Hanna Barchéus, Alba Corell, Malin Blomstrand, Thomas Olsson Bontell et autres
Background Suspected malignant lesions in the brain unamenable for resection are most often biopsied to establish the histomolecular diagnosis, guiding further treatment. Herein, we compare the postoperative outcomes in terms of safety and diagnostic yield between traditional and more recent biopsy techniques …
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Accès ouvert
2025
article
OpenAlex
Isabelle Rydén, Francesco Latini, Åsa Alberius Munkhammar, Per Hellström et autres
BACKGROUND: Management of isocitrate dehydrogenase (IDH) mutated gliomas is multidisciplinary and current guidelines support early multimodal treatment. The effects of this treatment approach on cognition are less studied. We aimed to study changes in cognitive functioning the first year following treatment in …
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Accès ouvert
2025
conference-abstract
OpenAlex
Alice Neimantaite, Francesco Latini, Markus Fahlström, Isabelle Rydén et autres
Abstract BACKGROUND Studies on brain and functional involvement with lower-grade gliomas (LGG) are typically restricted to predefined functionalities of interest, rather than data-driven. The brain functionality at risk has implications in surgical planning, cognitive testing, rehabilitation focus, and strategies such as supramarginal …
it, se
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Accès ouvert
2025
article
OpenAlex
Pernilla Ståhl, Ingela Henoch, Ramona Schenell, Bertil Rydenhag et autres
Abstract BACKGROUND Patients diagnosed with high-grade brain tumours and their relatives face significant challenges, necessitating the identification and development of effective support interventions. This scoping review aimed to systematically map existing support interventions for patients with glioblastoma or other primary high-grade brain …
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2025
conference-abstract
OpenAlex
Esperanza Tomás, Lina Leiss, Rasul M. Tabiev, Fredrik Nysjö et autres
Abstract This study tests the hypothesis that quantitative profiling of cell type composition and tissue architecture in isocitrate dehydrogenase (IDH)-mutant gliomas can provide valuable insights into tumor aggressiveness, treatment response, and survival. Towards this goal, we have established a novel method to …
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Accès ouvert
2025
article
OpenAlex
Alice Neimantaite, Louise Carstam, Tomás Gómez Vecchio, Ida Häggström et autres
PURPOSE: Adult patients with diffuse lower-grade gliomas (dLGG) show heterogeneous survival outcomes, complicating postoperative treatment planning. Treating all patients early increases the risk of long-term side effects, while delayed treatment may lead to impaired survival. Refinement of prognostic models could optimize timing …
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Accès ouvert
2025
article
OpenAlex
Alice Neimantaite, Tomás Gómez Vecchio, Isabelle Rydén, Dima Harba et autres
PURPOSE: Patients with diffuse lower-grade gliomas (LGG) often suffer from mental fatigue. In healthy subjects, mental fatigue has a negative impact on cognitive functioning. This relation may be more complex in LGG, where tumor localization and growth rate also impact brain function. …
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Accès ouvert
2024
article
OpenAlex
Anneli Ozanne, Joakim Öhlén, Stina Nyblom, Asgeir Store Jakola et autres
Background: Malignant brain tumors often lead to death. While improving future treatments is essential, end-of-life care must also be addressed. To ensure equitable palliative care, understanding the place of death is crucial, as disparities may lead to inequity of care. This study …
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Accès ouvert
2024
conference-abstract
OpenAlex
Anneli Ozanne, Joakim Öhlén, Stina Nyblom, Asgeir Store Jakola et autres
Abstract BACKGROUND The treatment in malignant brain tumour is multimodal and consists of a combination of surgery, radiotherapy, and chemotherapy. The average survival differs depending on e.g. degree of malignancy and location. Potential palliative needs also need attention. This preliminary study seeks …
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