Cheryl S. Jaigobin

Thrombolysis With Tenecteplase for Minor Disabling Stroke

Yiran Zhang, Brian H Buck, Philip A. Barber, Kausik Chatterjee et autres

Importance: Outcomes following intravenous thrombolysis for minor ischemic stroke may vary based on the presence of disabling deficits. Objective: To determine whether intravenous tenecteplase improves outcomes according to US National Institutes of Health Stroke Scale (NIHSS) score-based definitions of pretreatment disabling deficits. …

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Impact of Brain Frailty on Clinical Presentation and Neurologic Recovery in Acute Ischemic Stroke Patients Undergoing Thrombectomy

Joachim Fladt, Faysal Benali, Tanaporn Jaroenngarmsamer, Fouzi Bala et autres

Background and ObjectivesBrain frailty impairs the ability to compensate for brain dysfunction and is linked to worse outcomes after stroke. Stroke severity at presentation is a key determinant of outcomes in acute ischemic stroke. This study aimed to examine the impact of …

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Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial

Amy Yu, Shabnam Vatanpour, Aravind Ganesh, Thalia Shoshana Field et autres

BACKGROUND: In this subanalysis of the TEMPO-2 (Tenecteplase Versus Standard of Care for Minor Ischaemic Stroke With Proven Occlusion) trial, a randomized clinical trial comparing tenecteplase and nonthrombolytic control in patients with minor stroke and symptomatic intracranial occlusion, we investigated sex differences …

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Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial

Shelagh B. Coutts, Sandeep Ankolekar, Ramana Appireddy, Juan Francisco Arenillas et autres

ca, gb, es, au, br, at, ie, fi, sg, nz, de (code pays fourni par la source)

Patent Foramen Ovale Closure in Older Patients With Stroke

Andy Yu-Der Wang, Peter Malcolm Rothwell, Jason Nelson, Jeffrey L. Saver et autres

BACKGROUND AND OBJECTIVES: Whether patent foramen ovale (PFO) closure benefits older patients with PFO and cryptogenic stroke is unknown because randomized controlled trials (RCTs) have predominantly enrolled patients younger than 60 years of age. Our objective was to estimate anticipated effects of …

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Endovascular Thrombectomy Treatment Effect in Direct vs Transferred Patients With Large Ischemic Strokes

Michael D. Hill, Muhammad Shazam Hussain, Michael G. Abraham, Santiago Ortega‐Gutiérrez et autres

Importance: Patients with large ischemic core stroke have poor clinical outcomes and are frequently not considered for interfacility transfer for endovascular thrombectomy (EVT). Objective: To assess EVT treatment effects in transferred vs directly presenting patients and to evaluate the association between transfer …

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Endovascular Thrombectomy for Large Ischemic Stroke Across Ischemic Injury and Penumbra Profiles

Amrou Sarraj, Ameer E Hassan, Michael G. Abraham, Santiago Ortega‐Gutiérrez et autres

Importance: Whether endovascular thrombectomy (EVT) efficacy for patients with acute ischemic stroke and large cores varies depending on the extent of ischemic injury is uncertain. Objective: To describe the relationship between imaging estimates of irreversibly injured brain (core) and at-risk regions (mismatch) …

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Mediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke

Faysal Benali, Nishita Singh, Joachim Fladt, Tanaporn Jaroenngarmsamer et autres

Importance: Age is a leading predictor of poor outcomes after brain injuries like stroke. The extent to which age is associated with preexisting burdens of brain changes, visible on neuroimaging but rarely considered in acute decision-making or trials, is unknown. Objectives: To …

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Development and Validation of a Postprocedural Model to Predict Outcome After Endovascular Treatment for Ischemic Stroke

Vicky Chalos, Esmée Venema, Maxim J.H.L. Mulder, Bob Roozenbeek et autres

Importance: Outcome prediction after endovascular treatment (EVT) for ischemic stroke is important to patients, family members, and physicians. Objective: To develop and validate a model based on preprocedural and postprocedural characteristics to predict functional outcome for individual patients after EVT. Design, Setting, …

nl, us, ca, au, gb, fr, es (code pays fourni par la source)

Time Course of Early Hematoma Expansion in Acute Spot-Sign Positive Intracerebral Hemorrhage: Prespecified Analysis of the SPOTLIGHT Randomized Clinical Trial

Fahad S Al-Ajlan, David J. Gladstone, Dongbeom Song, Kevin E. Thorpe et autres

Background: In the SPOTLIGHT trial (Spot Sign Selection of Intracerebral Hemorrhage to Guide Hemostatic Therapy), patients with a computed tomography (CT) angiography spot-sign positive acute intracerebral hemorrhage were randomized to rFVIIa (recombinant activated factor VIIa; 80 μg/kg) or placebo within 6 hours …

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Assessment of Discrepancies Between Follow-up Infarct Volume and 90-Day Outcomes Among Patients With Ischemic Stroke Who Received Endovascular Therapy

Aravind Ganesh, Johanna Maria Ospel, Bijoy K. Menon, Andrew M. Demchuk et autres

Importance: Some patients have poor outcomes despite small infarcts after endovascular therapy (EVT), while others with large infarcts do well. Understanding why these discrepancies occur may help to optimize EVT outcomes. Objective: To validate exploratory findings from the Endovascular Treatment for Small …

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Optimized Hemodynamic Assessment to Predict Stroke Risk in Vertebrobasilar Disease: Analysis From the VERiTAS Study

Alfred Pokmeng See, Dilip Kumar Pandey, Xinjian Du, Linda Rose‐Finnell et autres

Background Atherosclerotic vertebrobasilar disease is a significant etiology of posterior circulation stroke. The prospective observational VERiTAS (Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke) study demonstrated that distal hemodynamic status is a robust predictor of subsequent vertebrobasilar stroke risk. …

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