Tadafumi Asaoka

Tumor-associated high endothelial venules are associated with enhanced lymphocyte infiltration and favorable prognosis in resected hepatocellular carcinoma

Shu Aoyama, Takehiro Noda, Hirofumi Akita, Yosuke Mukai et autres

BACKGROUND: Tumor-infiltrating lymphocytes (TILs) are essential to effective immunotherapy for hepatocellular carcinoma (HCC). Among factors regulating TILs, tumor-associated high endothelial venules (TA-HEVs) have been identified in various cancers and may contribute to TIL recruitment. This study aimed to investigate the clinical significance …

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Assessment of surgical invasiveness in hepatobiliary and pancreatic surgeries by quantifying intraoperative energy expenditure: A comparison between laparoscopic and open surgery

Daisaku Yamada, Hirofumi Akita, Kazuki Sasaki, Yoshihiro Mukai et autres

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Post hoc subgroup analysis of neoadjuvant gemcitabine plus S1 vs gemcitabine plus nab paclitaxel in elderly resectable/borderline resectable pancreatic adenocarcinoma

Daisaku Yamada, Shogo Kobayashi, Hidenori Takahashi, Yoshifumi Iwagami et autres

This study aimed to evaluate the safety and feasibility of two neoadjuvant chemotherapy (NAC) regimens, gemcitabine plus nab-paclitaxel (GA) and gemcitabine plus S-1 (GS), for elderly patients (aged 75 years and older) with resectable and borderline resectable pancreatic ductal adenocarcinoma (R/BR-PDAC). A …

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Laparoscopic Liver Resection for Small, Solitary, Peripheral-Type Intrahepatic Cholangiocarcinoma, Based on Preoperative Prediction of Lymph Node Metastasis

Hirotoshi Takayama, Shogo Kobayashi, Kunihito Gotoh, Kazuki Sasaki et autres

Aim: Laparoscopic liver resection (LLR) for intrahepatic cholangiocarcinoma (ICC) is not as widespread as LLR for hepatocellular carcinoma or liver metastasis, mainly because ICC may require a lymph node dissection (LND). However, small, solitary, peripheral-type ICC rarely have lymph node metastasis (LNM). …

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Surgical outcomes of histopathological stage I pancreatic cancer with special reference to oncological differences between pStage I and ypStage I cases

Naoko Sekiguchi, Hidenori Takahashi, Shogo Kobayashi, Kazuki Sasaki et autres

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Clinical and Pathological Analysis of Perianal Paget’s Disease: A Case Report and Review of 89 Cases

Kae Ishii, Hidekazu Takahashi, Hiromi Tsuji, Watsapol Juavijitjan et autres

Background/Aim: Perianal Paget's disease (PPD) is an intraepithelial invasion of the perianal skin that is frequently associated with anorectal carcinoma. Rectal canal carcinoma with Pagetoid spread (PS) is a relatively rare disease, and few reports on its outcomes are available. The relatively …

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MicroRNA-26a-5p is a reliable biomarker in the adjuvant setting for pancreatic ductal adenocarcinoma

Y. Takeda, Daisaku Yamada, Shogo Kobayashi, Kazuki Sasaki et autres

Pancreatic ductal adenocarcinoma (PDAC) has a high recurrence rate even after radical resection because of subclinical tumors. To manage them, a reliable biomarker that can indicate the presence of subclinical tumors and predict their chemosensitivity is required. This study aimed to identify …

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miR-6855-5p Enhances Radioresistance and Promotes Migration of Pancreatic Cancer by Inducing Epithelial-Mesenchymal Transition via Suppressing FOXA1: Potential of Plasma Exosomal miR-6855-5p as an Indicator of Radiosensitivity in Patients with Pancreatic Cancer

Hiroki Ueda, Hidenori Takahashi, Shogo Kobayashi, Masahiko Kubo et autres

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Preoperative treatment response prediction for pancreatic cancer by multiple microRNAs in plasma exosomes: Optimization using machine learning and network analysis

Hiroki Ueda, Hidenori Takahashi, Ryoto Sakaniwa, Tetsuhisa Kitamura et autres

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Prognostic impact of aberrant right hepatic artery involvement in patients with pancreatic cancer: A multicenter retrospective cohort study

Hiroki Ueda, Hidenori Takahashi, Hirofumi Akita, Yoshito Tomimaru et autres

BACKGROUND AND OBJECTIVES: This study aimed to evaluate the prognostic value of aberrant right hepatic artery (A-RHA) involvement in patients with pancreatic cancer (PC). METHODS: This study enrolled 474 patients who underwent upfront pancreatectomy or neoadjuvant treatment for resectable (R) or borderline …

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The combination of gemcitabine plus an anti-FGFR inhibitor can have a synergistic antitumor effect on FGF-activating cholangiocarcinoma

Y. Ito, Daisaku Yamada, Shogo Kobayashi, Kazuki Sasaki et autres

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High standard uptake value of the primary lesion of hepatocellular carcinoma correlates with early recurrence after curative resection

Kazuya Kato, Takehiro Noda, Shogo Kobayashi, Chihiro Yamanaka et autres

Abstract Background Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is useful for detecting the presence of distant metastases in many types of cancer, including hepatocellular carcinoma (HCC). However, the clinical significance of the standard uptake value (SUV) in primary HCC lesions is …

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