Barry McLean

RNA Interference With Zilebesiran for Mild to Moderate Hypertension

George L. Bakris, Manish Saxena, Anil Gupta, Fadi Chalhoub et autres

Importance: Angiotensinogen is the most upstream precursor of the renin-angiotensin-aldosterone system, a key pathway in blood pressure (BP) regulation. Zilebesiran, an investigational RNA interference therapeutic, targets hepatic angiotensinogen synthesis. Objective: To evaluate antihypertensive efficacy and safety of different zilebesiran dosing regimens. Design, …

us, gb (code pays fourni par la source)

EFFECTS OF GELESIS200, AN ORAL SUPERABSORBENT HYDROGEL, ON POSTPRANDIAL INSULIN RESPONSE IN PEOPLE WITH PREDIABETES

Livio Luzi, Frank L. Greenway, Sam Miller, Erika Matejkova et autres

OBJECTIVEPostprandial hyperinsulinemia is associated with beta- cell dysfunction and development of type 2 diabetes. This analysis assessed the effect of Gelesis200 (GS200), an investigational oral superabsorbent hydrogel, on postprandial glucose and insulin response among people with prediabetes, in the LIGHT-UP study. METHODOLOGYThe …

Waist-to-height ratio is a predictor of weight loss with Gelesis200 treatment for people with overweight or obesity having prediabetes or type 2 diabetes in the LIGHT-UP study

Livio Luzi, Frank L. Greenway, Sam Miller, Erika Matejkova et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)