Hann‐Hsiang Chao

The Optimal Management of Patients with Prostate Cancer with Oligometastatic Disease and Low Metastatic Burden in the PSMA-PET Era

Menal Bhandari, Isaac Lasko, Jacob J. Pozin, Michael Chang et autres

Historically, systemic therapy has been the primary treatment for metastatic prostate cancer (MPC), with radiotherapy and surgery reserved for palliation. The recent literature suggests that adding local therapy (i.e., radiotherapy or surgery) to systemic therapy may improve survival for MPC patients with …

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Landscape of Genetic Alterations Underlying Hallmark Signature Changes in Cancer Reveals TP53-Aneuploidy Driven Metabolic Reprogramming

Marni B. McClure, Yasunori Kogure, Olufunmilayo Ibironke Olopade, Jonathan H. Shepherd et autres

The hallmark signatures based on gene expression capture core cancer processes. Through a pan-cancer analysis, we describe the overview of hallmark signatures across tumor types/subtypes and reveal significant relationships between these signatures and genetic alterations. TP53 mutation exerts diverse changes, including increased …

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Ursodeoxycholic acid is associated with a reduction in SARS‐CoV‐2 infection and reduced severity of COVID‐19 in patients with cirrhosis

Teresa Brevini, Allison Chin, David Edward Kaplan, Fotios Sampaziotis et autres

BACKGROUND AND AIMS: Studies have demonstrated that reducing farnesoid X receptor activity with ursodeoxycholic acid (UDCA) downregulates angiotensin-converting enzyme in human lung, intestinal and cholangiocytes organoids in vitro, in human lungs and livers perfused ex situ, reducing internalization of severe acute respiratory …

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Association of HDV infection and HCC, hepatic decompensation, and all-cause and liver-related death in a national cohort

Binu V. John, Dustin Bastaich, Mahmoud Manouchehri Amoli, Robert J. Wong et autres

BACKGROUND AND AIMS: HDV infection is the most severe form of chronic hepatitis. However, studies on outcomes and causes of death in a US-born population, with primarily horizontal transmission of HDV, are lacking. The aim of this study was to conduct a …

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Challenges and Opportunities in Developing an Oncology Clinical Trial Network in the United States Veterans Affairs Health Care System: The VA STARPORT Experience

Abhishek Ashok Solanki, Kevin Zheng, Alicia Skipworth, Lisa M. Robin et autres

The United States Veterans Affairs (VA) Health Care System has a strong history of conducting impactful oncology randomized clinical trials (RCTs). We developed a phase II/III RCT to test the use of metastasis-directed therapy in Veterans with oligometastatic prostate cancer (OMPC)-the first …

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Systemic and Tumor-directed Therapy for Oligometastatic Prostate Cancer: The SOLAR Phase 2 Trial in De Novo Oligometastatic Prostate Cancer

Nicholas George Nickols, Sonny Tsai, Nathanael Kane, Samantha Tran et autres

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Systemic and tumor-directed therapy for oligometastatic prostate cancer (SOLAR): A phase II trial for veterans with de novo oligometastatic prostate cancer.

Nicholas George Nickols, Sonny Tsai, Nathanael Kane, Silvia V. Diaz-Perez et autres

163 Background: Treatment paradigms for oligometastatic castration-sensitive prostate cancer patients are evolving. Molecular imaging improves staging, intensified systemic and primary tumor directed therapy improves survival, metastasis-directed therapy improves local control. The impact of combining these imaging and therapeutic approaches into a planned …

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Liver Stiffness Measurement and Risk Prediction of Hepatocellular Carcinoma After HCV Eradication in Veterans With Cirrhosis

Binu V. John, Yangyang Dang, David Edward Kaplan, Janice H. Jou et autres

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Increased posterior cingulate cortex blood flow in cancer-related fatigue

David M. Raizen, Rupal Bhavsar, Brendan T Keenan, Patrick Z. Liu et autres

Fatigue is a common symptom associated with cancer treatments. Brain mechanisms underlying cancer-related fatigue (CRF) and its progression following therapy are poorly understood. Previous studies have suggested a role of the default mode network (DMN) in fatigue. In this study we used …

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Liver stiffness measurement Baveno VII rule of 5 and risk of hepatocellular carcinoma after HCV eradication in patients with cirrhosis

Binu V. John, Yangyang Deng, David Edward Kaplan, Janice H. Jou et autres

Mo1554 REFRACTORY HEPATIC HYDROTHORAX IS ASSOCIATED WITH INCREASED MORTALITY COMPARED TO PATIENTS WITH CIRRHOSIS AND REFRACTORY ASCITES

Allison Chin, Dustin Bastaich, Bassam A Dahman, David Edward Kaplan et autres

Ursodeoxycholic acid is associated with a reduction in SARS‐CoV‐2 infection and reduced severity of COVID‐19 in patients with cirrhosis

Binu V. John, Dustin Bastaich, Gwilym James Webb, Teresa Brevini et autres

BACKGROUND AND AIMS: Studies have demonstrated that reducing farnesoid X receptor activity with ursodeoxycholic acid (UDCA) downregulates angiotensin-converting enzyme in human lung, intestinal and cholangiocytes organoids in vitro, in human lungs and livers perfused ex situ, reducing internalization of severe acute respiratory …

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