Profil bibliographique

Valerie Calvert

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

304Publications signalées

5945Citations signalées

1Affiliations récentes

Les institutions déclarées

George Mason University

Les domaines associés

Advanced Breast Cancer TherapiesPancreatic and Hepatic Oncology ResearchColorectal Cancer Treatments and StudiesAdvanced Biosensing Techniques and ApplicationsAdvanced Proteomics Techniques and Applications

Les publications récentes

Accès ouvert 2026 other OpenAlex

Figure 1 from Acquisition of Resistance to RAS Inhibition Is Associated with the Upregulation of Macropinocytosis through Both PI3K-Dependent and -Independent Signaling

Ryan Robb, Sarah E. Ackermann, Seamus Degan, Khalilah E. Taylor et autres

Downregulation of macropinocytosis is not sustained following genetic loss of KRAS in KRAS-mutant PDAC cell lines. A, Representative images of macropinosomes labeled with FITC–dextran (green) and nuclear DAPI stain (blue) in indicated KRAS-mutant PDAC cells transiently transfected with an siRNA oligonucleotide (10 …

0 citations

Accès ouvert 2026 other OpenAlex

Figure 3 from Acquisition of Resistance to RAS Inhibition Is Associated with the Upregulation of Macropinocytosis through Both PI3K-Dependent and -Independent Signaling

Ryan Robb, Sarah E. Ackermann, Seamus Degan, Khalilah E. Taylor et autres

PDAC cell lines with acquired resistance to pharmacologic inhibitors of RAS exhibit enhanced macropinocytosis. A, Schematic diagram showing the experimental design for generating cell lines with acquired resistance to MRTX1133 (G12Di) and RMC7797 (RASi). B, Representative images of macropinosomes labeled with FITC–dextran …

0 citations

Accès ouvert 2026 other OpenAlex

Figure 4 from Acquisition of Resistance to RAS Inhibition Is Associated with the Upregulation of Macropinocytosis through Both PI3K-Dependent and -Independent Signaling

Ryan Robb, Sarah E. Ackermann, Seamus Degan, Khalilah E. Taylor et autres

Upregulated macropinocytosis in RAS inhibitor-resistant cell lines is associated with increased uptake of and sensitivity to albumin-bound paclitaxel compared with free drug. A, Schematic diagram highlighting the differential routes through which free paclitaxel and albumin-bound nab-paclitaxel enter the cell. B, Representative images …

0 citations

Accès ouvert 2026 other OpenAlex

Figure S1 from Acquisition of Resistance to RAS Inhibition Is Associated with the Upregulation of Macropinocytosis through Both PI3K-Dependent and -Independent Signaling

Ryan Robb, Sarah E. Ackermann, Seamus Degan, Khalilah E. Taylor et autres

KRAS suppression results in a transient reduction in macropinocytosis

0 citations

Accès ouvert 2026 other OpenAlex

Figure 5 from Acquisition of Resistance to RAS Inhibition Is Associated with the Upregulation of Macropinocytosis through Both PI3K-Dependent and -Independent Signaling

Ryan Robb, Sarah E. Ackermann, Seamus Degan, Khalilah E. Taylor et autres

PDAC cell lines display both PI3K-dependent and -independent signaling supporting macropinocytosis. A, Schematic diagram delineating the experimental set-up for RPPA analysis and parallel validation via immunoblotting. B, RPPA Pearson correlation coefficients comparing cell lines and treatments based on the AUC following dimensionality …

0 citations

Accès ouvert 2026 other OpenAlex

Figure 6 from Acquisition of Resistance to RAS Inhibition Is Associated with the Upregulation of Macropinocytosis through Both PI3K-Dependent and -Independent Signaling

Ryan Robb, Sarah E. Ackermann, Seamus Degan, Khalilah E. Taylor et autres

Different RAS inhibitor-resistant PDAC cell lines activate RAC via distinct pathways to upregulate macropinocytosis. A, Diagram of signaling pathways relevant to macropinocytosis that focuses on the central role of RAC activation downstream of RAS, PI3K, and FAK signaling. B, Immunoblotting of indicated …

0 citations

Accès ouvert 2026 other OpenAlex

Figure S9 from Acquisition of Resistance to RAS Inhibition Is Associated with the Upregulation of Macropinocytosis through Both PI3K-Dependent and -Independent Signaling

Ryan Robb, Sarah E. Ackermann, Seamus Degan, Khalilah E. Taylor et autres

Pictilisib treatment impairs growth and PI3K signaling in PDAC cell lines

0 citations

Accès ouvert 2026 other OpenAlex

Figure S11 from Acquisition of Resistance to RAS Inhibition Is Associated with the Upregulation of Macropinocytosis through Both PI3K-Dependent and -Independent Signaling

Ryan Robb, Sarah E. Ackermann, Seamus Degan, Khalilah E. Taylor et autres

Pictilisib (PI3Ki) treatment decreases PI3K-mediated signaling in PDAC cell lines

0 citations

Accès ouvert 2026 other OpenAlex

Figure S2 from Acquisition of Resistance to RAS Inhibition Is Associated with the Upregulation of Macropinocytosis through Both PI3K-Dependent and -Independent Signaling

Ryan Robb, Sarah E. Ackermann, Seamus Degan, Khalilah E. Taylor et autres

Prolonged RAS pathway inhibition in KRAS-mutant PDAC cells results in increased macropinocytosis

0 citations

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Figure S8 from Acquisition of Resistance to RAS Inhibition Is Associated with the Upregulation of Macropinocytosis through Both PI3K-Dependent and -Independent Signaling

Ryan Robb, Sarah E. Ackermann, Seamus Degan, Khalilah E. Taylor et autres

PDAC cell lines display both PI3K-dependent and -independent signaling supporting macropinocytosis

0 citations

Accès ouvert 2026 other OpenAlex

Figure S13 from Acquisition of Resistance to RAS Inhibition Is Associated with the Upregulation of Macropinocytosis through Both PI3K-Dependent and -Independent Signaling

Ryan Robb, Sarah E. Ackermann, Seamus Degan, Khalilah E. Taylor et autres

A subset of RASi-resistant PDAC cell lines activates YAP and/or TAZ to upregulate macropinocytosis

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Accès ouvert 2026 other OpenAlex

Figure S7 from Acquisition of Resistance to RAS Inhibition Is Associated with the Upregulation of Macropinocytosis through Both PI3K-Dependent and -Independent Signaling

Ryan Robb, Sarah E. Ackermann, Seamus Degan, Khalilah E. Taylor et autres

RPPA analysis of PDAC cell line panel treated with RAS ERK MAPK inhibitors for 24 to 168 hours

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