Pawel Kostyrko

Brain-derived tau for monitoring brain injury in acute ischemic stroke

Naomi Vlegels, Nicoló Luca Knuth, Konstantin A. Steiner, Linjie Zhang et autres

A specific and accurate blood test for acute brain injury could help monitor infarct growth in ischemic stroke and serve as a surrogate end point in clinical trials. Using a single-molecule detection assay, we assessed plasma brain-derived tau (BD-tau), a marker selectively …

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Thrombolysis With Tenecteplase for Minor Disabling Stroke

Yiran Zhang, Brian Buck, Philip A. Barber, Kausik Chatterjee et autres

Importance: Outcomes following intravenous thrombolysis for minor ischemic stroke may vary based on the presence of disabling deficits. Objective: To determine whether intravenous tenecteplase improves outcomes according to US National Institutes of Health Stroke Scale (NIHSS) score-based definitions of pretreatment disabling deficits. …

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Thrombolysis With Tenecteplase for Minor Disabling Stroke

Yiran Zhang, Brian H Buck, Philip A Barber, Kausik Chatterjee et autres

Importance: Outcomes following intravenous thrombolysis for minor ischemic stroke may vary based on the presence of disabling deficits. Objective: To determine whether intravenous tenecteplase improves outcomes according to US National Institutes of Health Stroke Scale (NIHSS) score–based definitions of pretreatment disabling deficits. …

Impact of Brain Frailty on Clinical Presentation and Neurologic Recovery in Acute Ischemic Stroke Patients Undergoing Thrombectomy

Joachim Fladt, Faysal Benali, Tanaporn Jaroenngarmsamer, Fouzi Bala et autres

Background and ObjectivesBrain frailty impairs the ability to compensate for brain dysfunction and is linked to worse outcomes after stroke. Stroke severity at presentation is a key determinant of outcomes in acute ischemic stroke. This study aimed to examine the impact of …

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Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial

Amy Yu, Shabnam Vatanpour, Aravind Ganesh, Thalia S. Field et autres

BACKGROUND: In this subanalysis of the TEMPO-2 (Tenecteplase Versus Standard of Care for Minor Ischaemic Stroke With Proven Occlusion) trial, a randomized clinical trial comparing tenecteplase and nonthrombolytic control in patients with minor stroke and symptomatic intracranial occlusion, we investigated sex differences …

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Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial

Shelagh B. Coutts, Sandeep Ankolekar, Ramana Appireddy, Juan F. Arenillas et autres

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Mediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke

Faysal Benali, Nishita Singh, Joachim Fladt, Tanaporn Jaroenngarmsamer et autres

Importance: Age is a leading predictor of poor outcomes after brain injuries like stroke. The extent to which age is associated with preexisting burdens of brain changes, visible on neuroimaging but rarely considered in acute decision-making or trials, is unknown. Objectives: To …

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Development and Validation of a Postprocedural Model to Predict Outcome After Endovascular Treatment for Ischemic Stroke

Vicky Chalos, Esmée Venema, Maxim J.H.L. Mulder, Bob Roozenbeek et autres

Importance: Outcome prediction after endovascular treatment (EVT) for ischemic stroke is important to patients, family members, and physicians. Objective: To develop and validate a model based on preprocedural and postprocedural characteristics to predict functional outcome for individual patients after EVT. Design, Setting, …

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Time Course of Early Hematoma Expansion in Acute Spot-Sign Positive Intracerebral Hemorrhage: Prespecified Analysis of the SPOTLIGHT Randomized Clinical Trial

Fahad Al-Ajlan, David J. Gladstone, Dongbeom Song, Kevin E. Thorpe et autres

Background: In the SPOTLIGHT trial (Spot Sign Selection of Intracerebral Hemorrhage to Guide Hemostatic Therapy), patients with a computed tomography (CT) angiography spot-sign positive acute intracerebral hemorrhage were randomized to rFVIIa (recombinant activated factor VIIa; 80 μg/kg) or placebo within 6 hours …

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Determining whether Sex and Zygosity modulates the association between ApoE4 and Psychosis in Neurodegenerative Disease Cohorts using the ONDRI platform

Mila Valcic, Sandra E. Black, Morris Freedman, Michael Borrie et autres

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Assessment of Discrepancies Between Follow-up Infarct Volume and 90-Day Outcomes Among Patients With Ischemic Stroke Who Received Endovascular Therapy

Aravind Ganesh, Johanna M. Ospel, Bijoy K. Menon, Andrew M. Demchuk et autres

Importance: Some patients have poor outcomes despite small infarcts after endovascular therapy (EVT), while others with large infarcts do well. Understanding why these discrepancies occur may help to optimize EVT outcomes. Objective: To validate exploratory findings from the Endovascular Treatment for Small …

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Effect of an Educational Intervention on Therapeutic Inertia in Neurologists With Expertise in Multiple Sclerosis

Gustavo Saposnik, Marcus Grueschow, Jiwon Oh, María Terzaghi et autres

Importance: Therapeutic inertia (TI) is the failure to escalate therapy when treatment goals are unmet and is associated with low tolerance to uncertainty and aversion to ambiguity in physician decision-making. Limited information is available on how physicians handle therapeutic decision-making in the …

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