Accès ouvert
2026
article
OpenAlex
Marco Fiore, Michele Pellegrino, Giuseppe Cirillo, Ludovica Scorzafave et autres
This work reports the synthesis and characterization of sustainable, multifunctional chitosan/graphene oxide hybrid nanoparticles (GOCSNPs) prepared via a low-temperature ionotropic gelation method utilizing sodium tripolyphosphate as a green crosslinker. Combined DLS and TEM analyses confirmed the successful formation of submicron spherical nanoparticles …
it
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Accès ouvert
2026
review
OpenAlex
Manuela Curcio, Federica Saletta, Ludovica Scorzafave, Marco Fiore et autres
Cancer progression is closely associated with dysregulated redox homeostasis within the tumour microenvironment (TME), where reactive oxygen and nitrogen species influence tumour survival, immune evasion, and therapeutic resistance. While physiological redox signalling supports antitumour immunity, persistent oxidative stress promotes immunosuppression and limits …
it, au
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Accès ouvert
2026
article
OpenAlex
Ludovica Scorzafave, Michele Pellegrino, Giuseppe Cirillo, Marco Fiore et autres
In this study, a pH-responsive chondroitin sulfate–methotrexate (MTX) polymeric prodrug was synthesized through Schiff base formation between oxidized chondroitin sulfate and MTX. The resulting amphiphilic conjugate exhibited a conjugation degree of 184 mg MTX per g conjugate and spontaneously self-assembled into stable …
it
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Accès ouvert
2025
article
OpenAlex
Ludovica Scorzafave, Marco Fiore, Giuseppe Cirillo, Fiore Pasquale Nicoletta et autres
Chondroitin sulfate (CS)-based nanoparticles have emerged as versatile and multifunctional platforms for cancer therapy, integrating effective drug delivery with diagnostic capabilities. Their ability to exploit the enhanced permeability and retention (EPR) effect enables selective accumulation within tumor tissues, while surface modification with …
it
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Accès ouvert
2025
article
OpenAlex
Serena Pelusi, Chiara Macchi, Sara Margarita, Irene De Matteis et autres
BACKGROUND: The relationship between plasma lipoprotein(a) [Lp(a)] levels and metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear. The aim of this study was to examine the combined effects of Lp(a) levels on liver and vascular damage. METHODS: The study was conducted using …
it, es, fr
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Accès ouvert
2025
article
OpenAlex
Manuela Curcio, Natalia Pediconi, Martina Brunetti, Zaira Spinello et autres
Cystamine-derivatized Human Serum Albumin (HSAcys) was tested as a redox-responsive cationic specimen for microRNA (miRNA) vectorization to triple-negative breast cancer (TNBC) cells. MiR-139-5p was used as gene material, since it is significantly down-regulated in TNBC, thus suggesting its re-introduction as a promising …
it
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Accès ouvert
2025
article
OpenAlex
Ludovica Scorzafave, Eugenia Nicol Manti, Marco Fiorillo, Manuela Curcio et autres
In this study, a smart hybrid liposome system was achieved combining a self-assembling biopolymer conjugate (human serum albumin-hyaluronic acid) with targeting and redox-responsive activity with dioleoyl phosphatidylethanolamine, a fusogenic phospholipid. The obtained hybrid liposomal structures were found to possess suitable physicochemical properties …
it
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Accès ouvert
2024
article
OpenAlex
Giuseppe Cirillo, Anna Rita Cappello, Manuela Curcio, Marco Fiorillo et autres
This study introduces novel CD44-targeted and redox-responsive nanoparticles (FNPs), proposed as doxorubicin (DOX) delivery devices for breast cancer. A cationized and redox-responsive Human Serum Albumin derivative was synthesized by conjugating Human Serum Albumin with cystamine moieties and then ionically complexing it with …
it
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Accès ouvert
2024
article
OpenAlex
Lorenzo Francesco Madeo, Christine Schirmer, Giuseppe Cirillo, A. Asha et autres
A ZnO-Graphene oxide nanocomposite (Z-G) was prepared in order to exploit the biomedical features of each component in a single anticancer material. This was achieved by means of an environmentally friendly synthesis, taking place at a low temperature and without the involvement …
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Accès ouvert
2024
article
OpenAlex
Ensieh M. Poursani, Giuseppe Cirillo, Manuela Curcio, Orazio Vittorio et autres
In this study, we developed self-assembling nanoparticles (LCPs) able to trigger the release of Chlorambucil (Chl) and Doxorubicin (DOX) to MDA-MB-231 cells by exploiting the enzyme and redox signals. The DOX loaded LCPs was prepared by the self-assembly of two chondroitin sulphate …
au, it
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Accès ouvert
2023
article
OpenAlex
Giuseppe Cirillo, Manuela Curcio, Cesare Oliviero Rossi, Giovanni De Filpo et autres
The conjugation of polyphenols is a valuable strategy with which to confer tailored properties to polymeric materials of biomedical interest. Within this investigation, we aim to explore the possibility to use this synthetic approach to increase the viscosity of conjugates, thus allowing …
it
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Accès ouvert
2023
article
OpenAlex
Mariagrazia Di Luca, Ensieh M. Poursani, Manuela Curcio, Giuseppe Cirillo et autres
Abstract With the objective of creating an electro‐responsive and antimicrobial device suitable as delivery system for Rose Bengal (RB) to the skin, a hybrid hydrogel combining Chitosan (CS) and Graphene Oxide (GO) are designed, serving as functional polymer support and active filling …
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