Antje Garten

Established polygenic risk score for hypercholesterinemia demonstrates discriminatory value and risk stratification in an independent German Cohort

Akhil Velluva, Linnaeus Bundalian, Erind Gjermeni, Julius Katzmann et autres

Abstract Polygenic risk scores (PRS) have emerged as promising tools for stratifying inherited disease risk, yet their translation into clinical practice is constrained by a critical and frequently unmet requirement: demonstration that scores derived in one cohort retain discriminatory value when applied …

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In vitro study of TSC1 deficiency in preadipocytes: insights into development and treatment options for tuberous sclerosis related lipomatosis

Julika E. Friedrich, Julia Hentschel, Sandy Richter, Henriette Kiep et autres

BACKGROUND: Tuberous sclerosis complex (TSC) is a rare genetic neurocutaneous disorder resulting from mutations in the TSC1 or TSC2 genes, characterized by overgrowth and lesions in multiple organs. While renal angiomyolipomas are commonly seen, lipomas located elsewhere are rarely reported in these …

de (code pays fourni par la source)

In vitro study of TSC1 deficiency in preadipocytes: insights into development and treatment options for tuberous sclerosis related lipomatosis

Julika E. Friedrich, Julia Hentschel, Sandy Richter, Henriette Kiep et autres

Abstract Background Tuberous sclerosis complex (TSC) is a rare genetic neurocutaneous disorder resulting from mutations in the TSC1 or TSC2 genes, characterized by overgrowth and lesions in multiple organs. While renal angiomyolipomas are commonly seen, lipomas located elsewhere are rarely reported in …

de (code pays fourni par la source)

Additional file 1 of In vitro study of TSC1 deficiency in preadipocytes: insights into development and treatment options for tuberous sclerosis related lipomatosis

Julika E. Friedrich, Julia Hentschel, Sandy Richter, Henriette Kiep et autres

Supplementary Material 1: Table S1: SVF cell cultures. Table S2: Primers used for qPCR. Table S3: Antibodies used for Western Blot (Wb) and immunofluorescence staining (IF). Fig. S1: Uncropped Western Blot (Wb) panels for Fig. 2c. Fig. S2: Uncropped Western Blot (Wb) …

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Additional file 2 of In vitro study of TSC1 deficiency in preadipocytes: insights into development and treatment options for tuberous sclerosis related lipomatosis

Julika E. Friedrich, Julia Hentschel, Sandy Richter, Henriette Kiep et autres

Supplementary Material 2: Supplementary Table S4: Table containing data corresponding to the graphs presented in the manuscript.

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Additional file 1 of In vitro study of TSC1 deficiency in preadipocytes: insights into development and treatment options for tuberous sclerosis related lipomatosis

Julika E. Friedrich, Julia Hentschel, Sandy Richter, Henriette Kiep et autres

Supplementary Material 1: Table S1: SVF cell cultures. Table S2: Primers used for qPCR. Table S3: Antibodies used for Western Blot (Wb) and immunofluorescence staining (IF). Fig. S1: Uncropped Western Blot (Wb) panels for Fig. 2c. Fig. S2: Uncropped Western Blot (Wb) …

de (code pays fourni par la source)

In vitro study of TSC1 deficiency in preadipocytes: insights into development and treatment options for tuberous sclerosis related lipomatosis

Julika E. Friedrich, Julia Hentschel, Sandy Richter, Henriette Kiep et autres

Abstract Background Tuberous sclerosis complex (TSC) is a rare genetic neurocutaneous disorder resulting from mutations in the TSC1 or TSC2 genes, characterized by overgrowth and lesions in multiple organs. While renal angiomyolipomas are commonly seen, lipomas located elsewhere are rarely reported in …

de (code pays fourni par la source)

Additional file 2 of In vitro study of TSC1 deficiency in preadipocytes: insights into development and treatment options for tuberous sclerosis related lipomatosis

Julika E. Friedrich, Julia Hentschel, Sandy Richter, Henriette Kiep et autres

Supplementary Material 2: Supplementary Table S4: Table containing data corresponding to the graphs presented in the manuscript.

de (code pays fourni par la source)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R / AKT pathway

Yujia Guo, Sandy Richter, Christoph Bach, W Kiess et autres

Adipogenesis involves preadipocyte proliferation and differentiation into mature adipocytes, with dysregulation of this process being associated with changes in metabolic health. Here, we aimed to evaluate the effect of IGFBP4 knockdown (KD) on human preadipocytes and define if this altered IGF1 signaling. …

de, us, pl (code pays fourni par la source)

A conserved transcriptomic model defines metabolic resilience and vulnerability in obesity

Yin-Yuan Su, Lolet T Bundalian, Yin-Cheng Chen, Erind Gjermeni et autres

Abstract Background Obesity arises from a complex interplay of genetic and environmental factors, with alterations of transcriptional networks that integrate metabolic, immune, and regulatory pathways. Conventional measures such as body mass index (BMI) quantify body size but fail to capture the molecular …

tw, de, it, ch (code pays fourni par la source)

Author response for "Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway"

Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess et autres

Author response for "Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway"

Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess et autres