Jonas Paludo

Abstract 2740: Applications of large language models to CAR-T cell therapy clinical data using Google cloud computing.

Emmanuel Contreras Guzman, Matthew Jankowski, Andre de Menezes Silva Corraes, Malvika Gupta et autres

Abstract Large Language Models (LLM) are being widely adopted into the medical field for their impressive ability to analyze and summarize large amounts of text data. These models enable clinicians and researchers to extract meaningful insights from complex datasets and may assist …

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Abstract 1213: Mitochondrial transcriptome profiles associated with clinical responses to CAR-T therapy in aggressive lymphoma.

Jacqueline A. Turner, Panwen Wang, Patrizia Mondello, Melinda Tan et autres

Abstract Introduction: Therapeutic outcomes in B-cell non-Hodgkin’s lymphoma (B-NHL) have substantially improved with the introduction of chimeric antigen receptor T-cell (CAR-T) therapy. Yet, persistent immune dysfunction and underlying metabolic dysregulation remain major obstacles to achieving durable clinical responses in B-NHL. We hypothesize …

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Abstract 3278: Metabolic pathway signatures defining response to CD19 CAR T-Cell therapy in aggressive B-cell non-hodgkin lymphoma

Melinda S.Y. Tan, Panwen Wang, Patrizia Mondello, Jacqueline A. Turner et autres

Abstract Chimeric antigen receptor (CAR) T-cell therapy achieves high response rates in relapsed/refractory aggressive B-cell non-Hodgkin lymphoma, yet only 40% of patients achieve durable remission. Identifying biological programs linked to long-term response remains critical. As metabolic fitness underlies T-cell persistence and effector …

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Optimizing Low Dose Radiotherapy for Indolent Lymphomas: Comparing 4 Gy x 2 vs. 2 Gy x 2

J.F. Burlile, W.Scott Harmsen, Omran Saifi, Brady Laughlin et autres

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Comprehensive Salvage Radiotherapy for Limited Relapsed B-Cell Non-Hodgkin Lymphoma Following CD19 Chimeric Antigen Receptor T-Cell Therapy

Omran Saifi, W. Breen, S.C. Lester, W.G. Rule et autres

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The Impact of Radiation Timing in Peri-CAR T-Cell Therapy on Local Control for Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma

Omran Saifi, W. Breen, S.C. Lester, W.G. Rule et autres

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