Jihong Yao

MiR-381-3p targets the CREB1/PRDX6 axis to regulate ferroptosis in intestinal ischemia/reperfusion injury

J Q Liu, Haochen Zou, Mengze Huang, Chengjun Zhuang et autres

Ferroptosis, an iron-dependent type of cell death, has attracted significant attention in recent years. Accumulating evidence demonstrates that ferroptosis critically contributes to the pathogenesis of intestinal ischemia/reperfusion (I/R) primarily through triggering excessive lipid peroxidation, disrupting iron homeostasis, and disabling endogenous antioxidant system. …

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CAND1 drives intestinal ischemia/reperfusion injury via SCFFBXO6-PKM2-mediated mitochondrial fission and apoptosis

强苗苗, Y Zhao, Guorong Wang, Zhao Chen et autres

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rRGD3mu, a Triple-RGD Recombinant Peptide, Suppresses Malignant Phenotypes in Nasopharyngeal Carcinoma-Associated Models Through the Modulation of ITGB1-Associated FAK/AKT Signaling

Qianhui Yuan, Fuxin Zhou, X.C. Li, Jingyu Zhang et autres

Nasopharyngeal carcinoma-associated malignant epithelial models remain useful for exploring integrin-related therapeutic strategies. In this study, we evaluated the antitumor activity and potential mechanisms of rRGD3mu, a recombinant peptide with a triple-RGD architecture. Using CNE2 cells as the primary experimental model, we evaluated …

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HRD1 promotes chronic alcoholic liver disease by mediating ACSL3 ubiquitination and degradation

Lu Meng, Yan Wei Hu, Xuzi Zhao, Zhecheng Wang et autres

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USP5-induced deubiquitination of P4HB alleviates ER stress-mediated apoptosis in intestinal ischemia/reperfusion

Shili Ning, Xuzi Zhao, Yan Zhao, Fengyuan Yang et autres

Intestinal ischemia/reperfusion (I/R) is a severe pathophysiological process that occurs in a variety of clinical conditions and can trigger multiple life-threatening syndromes. Intestinal I/R is associated endoplasmic reticulum (ER) stress. Prolyl 4-hydroxylase subunit beta (P4HB) contributes significantly to maintaining ER redox homeostasis, …

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N6-methyladenosine reader IGF2BP2 regulates NIPSNAP1-mediated mitophagy and mitochondrial dynamics to alleviate hepatic ischemia-reperfusion injury

Shanshan Guo, Yan Zhao, Yan Wei Hu, Xinying Wang et autres

BACKGROUND Hepatic ischemia-reperfusion (I/R) injury related to liver transplantation and hepatic resection remains a challenge in clinical practice. Accumulating evidence indicates that mitochondrial dysfunction is a critical cause of I/R injury. The protein 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1) …

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OTUB1 enhances fatty acid oxidation in APAP-induced liver injury by mediating ACSL5 deubiquitination

Shuyu Guo, Yan Dong Zhao, Yue Wang, Xuzi Zhao et autres

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Deacetylation of BAP31 by sirtuin 2 attenuates apoptosis of hepatocytes induced by endoplasmic reticulum stress, in chronic alcoholic liver injury

Sai Wang, Yufeng Wang, Wen Shan, Guo‐Yang Li et autres

BACKGROUND AND PURPOSE: Endoplasmic reticulum (ER) stress is a crucial pathogenic mechanism in alcoholic liver disease (ALD). B-cell receptor-associated protein 31 (BAP31) can regulate ER homeostasis and anti-apoptosis, but the function and regulation of BAP31 in ALD are unclear. The purpose of …

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A novel protein encoded by circARHGAP12 attenuates DNA damage and apoptosis by regulating MDC1 in intestinal ischemia/reperfusion injury

Deshun Liu, Xuzi Zhao, Zhecheng Wang, Guangzhi Wang et autres

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A novel peptide encoded by circ‐SLC9A6 promotes lipid dyshomeostasis through the regulation of H4K16ac‐mediated CD36 transcription in NAFLD

Yue Wang, Xinyao Tian, Zhecheng Wang, Deshun Liu et autres

BACKGROUND: As the leading cause of end-stage liver disease, nonalcoholic fatty liver disease (NAFLD) is mainly induced by lipid dyshomeostasis. The translation of endogenous circular RNAs (circRNAs) is closely related to the progression of various diseases, but the involvement of circRNAs in …

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HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion

Xuzi Zhao, Deshun Liu, Yan Zhao, Zhecheng Wang et autres

Intestinal ischemia/reperfusion (I/R) injury is a typical pathological course in the clinic with a high morbidity rate. Recent research has pointed out the critical role of ubiquitination during the occurrence and development of intestinal I/R by precisely mediating protein quality control and …

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MAPK1 Mediates MAM Disruption and Mitochondrial Dysfunction in Diabetic Kidney Disease via the PACS-2-Dependent Mechanism

S. Liu, Shuai Han, Cuili Wang, Hongjun Chen et autres

Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease (ESRD). Mitochondrial dysfunction in renal tubules, occurring early in the disease, is linked to the development of DKD, although the underlying pathways remain unclear. Here, we examine diabetic human and …

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