Dai‐Wen Pang

Intermolecular Hydrogen Bonding Modulates Triplet–Triplet Annihilation Upconversion in a Cationic Sensitizer as Revealed by Transient Electronic Spectroscopy

Dongxue Guo, Yu Li, Zi-Yu Wang, Xin-Yu Liu et autres

Abstract Metal-free triplet–triplet annihilation upconversion (TTA-UC) under long-wavelength excitation rules out metal toxicity and improves biocompatibility, showing great potential for biomedical use of photon upconversion materials. Intermolecular hydrogen bonding commonly occurs in biological environments, yet its effects on organic upconversion performance have …

cn (code pays fourni par la source)

HClO-Activatable Organelle-Targeted Theranostic Probes for Real-Time Imaging and On-Demand Elimination of H1N1-Infected Cells

Zi-Lu Li, Ai-Xin Ma, Jun-Yu Zhou, Hao Wang et autres

Abstract Influenza A (H1N1) virus infection disrupts intracellular homeostasis, inducing endoplasmic reticulum (ER) stress, Golgi apparatus stress, and elevated hypochlorous acid (HClO) production. Simultaneously visualizing these events and intervening in a timely manner is crucial for both infection progression assessment and effective …

cn (code pays fourni par la source)

Naked-eye and fluorescence dual-mode nanomaterials for intraoperative guidance in breast cancer surgical navigation

Guoping Chen, Chenchen Li, Pir Muhammad, Yan Wang et autres

NIR-II Ratiometric Imaging of SOD Activity with a Superoxide-Responsive Nanoprobe

Rentang Huang, Qing‐Qing Ye, Liang Zhao, Han Zhu et autres

Superoxide dismutase (SOD) maintains redox homeostasis, and its activity reflects oxidative stress in aging, inflammation, and diseases. However, real-time monitoring of SOD activity in vivo remains challenging. Here we constructed a superoxide anion radical (O2•-)-responsive NIR-II ratiometric probe based on a "substrate-monitoring …

cn (code pays fourni par la source)

Correction to “Triplet-Mediated Photon Upconversion via Near-Infrared-II Excitation without Tetracene Derivatives”

Ran Li, Lin-Han Jiang, Dongxue Guo, Ying-Ze Li et autres

Triplet-Mediated Photon Upconversion via Near-Infrared-II Excitation without Tetracene Derivatives

Ran Li, Lin-Han Jiang, Dongxue Guo, Yu Li et autres

Nearly all triplet-mediated near-infrared (NIR, over 800 nm) photon upconversion materials have traditionally relied on tetracene derivatives as surface ligands or annihilators. However, the inherent limitations of these compounds, such as poor stability and limited energy level tunability, have significantly impeded the …

cn (code pays fourni par la source)

Geneticability of Live‐Cell Site‐Specific Synthesis of Quantum Dots

Qianqian Sun, Hai‐Yan Xie, Yusi Hu, Juan Kong et autres

Abstract Molecular‐scale integration of non‐natural functional components into living systems for precise manipulation, monitoring, and enhancement of organisms remains a great challenge. Here, we achieved the geneticable synthesis of functional inorganic nanomaterials with molecular‐level spatial precision within live mammalian cells. By genetically …

cn (code pays fourni par la source)

Geneticability of Live‐Cell Site‐Specific Synthesis of Quantum Dots

Qianqian Sun, Hai‐Yan Xie, Yusi Hu, Juan Kong et autres

Molecular-scale integration of non-natural functional components into living systems for precise manipulation, monitoring, and enhancement of organisms remains a great challenge. Here, we achieved the geneticable synthesis of functional inorganic nanomaterials with molecular-level spatial precision within live mammalian cells. By genetically encoding …

cn (code pays fourni par la source)

Mapping the Functional Architecture of Influenza A Virus-Induced Phase Separation through m 6 A Proximity Labeling

Zhaoguo He, Yifan Wang, Riming Huang, Yusi Hu et autres

The precise spatial organization of biomolecules on the nanoscale is fundamental to cellular function. However, the molecular mechanisms governing this intricate architecture remain largely unexplored, particularly the role of RNA chemical modifications such as N6-methyladenosine (m 6 A) in orchestrating nanoscale order …

cn, de (code pays fourni par la source)

Spatial Mapping and Interactome Profiling of m 6 A-Modified R-Loops via Chemically Inducible Split-APEX2 Proximity Labeling

Zhaoguo He, Yao Cheng, Qing‐Qing Ye, Zhi‐Gang Wang et autres

m 6 A-Modified R-loops (m 6 A-R-loops) play crucial roles in epigenetic regulation and genome stability, yet resolving their spatial distribution and protein interactomes in live cells remains challenging. To address this, we developed m 6 A-R-loop proximity labeling (m 6 A-RLPL), …

cn (code pays fourni par la source)

Programmable targeted RNA degradation via dCas13d-directed chaperone-mediated autophagy (dCasCMA)

Hui‐Ping Wen, Cong Yu, Shuli Bi, Lin‐Han Jiang et autres

RNA-targeted degradation technologies offer significant promise for treating diseases by selectively disrupting gene expression. However, a robust method to specifically, efficiently, and programmability degrade targeted RNAs in mammalian cells is still in demand. Here, we present a versatile platform, dCas13d-directed chaperone-mediated autophagy …

cn (code pays fourni par la source)

SELEX-HTCFQ Platform: Developing DNA Enhancers of ADAR1 to Suppress ZBP1-Dependent Immunopathology

Yafei Hu, Riming Huang, Yifan Wang, Zhu Han et autres

Excessive immune activation drives pathological inflammation through dysregulated ZBP1 signaling, yet this sensor remains crucial for immune surveillance, necessitating targeted therapies that selectively inhibit pathology, while preserving protective functions. Here, we developed an innovative SELEX-HTCFQ platform that combines the Systematic Evolution of …

cn (code pays fourni par la source)