Małgorzata Oczko‐Wojciechowska

Characterisation of somatic genetic alterations in sporadic medullary thyroid carcinoma

Hanna Langer-Macioł, Dagmara Rusinek, Małgorzata Kowalska, Aleksandra Pfeifer et autres

OC7.1 - ECE_2484 - Pancreatic neuroendocrine neoplasms share germline DNA repair gene predisposition with breast, ovarian and colorectal cancer syndromes (BRCA2, CHEK2 and MMR)

Beata Jurecka‐Lubieniecka, Małgorzata Roś-Mazurczyk, Aleksandra Syguła, Alexander Cortez et autres

Abstract Mutations in DNA repair genes are major drivers of both hereditary and sporadic malignancies, including breast, ovarian, prostate, colorectal adenocarcinoma, and pancreatic cancer. Familial tumors are typically associated with earlier onset and a more aggressive clinical phenotype. Advances in diagnostics and …

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Crucial role of IL-6, IL-8, IL-11 and leptin in tumor microenvironment in a group of patients with GEP-NETs- crosstalk between inflammation and cancer

Agata Świętek, Joanna K. Strzelczyk, Dorota Hudy, Zenon Czuba et autres

Introduction: GEP-NETs constitute a heterogeneous group of rare cancers arising in biologically diverse microenvironments, while their cytokine profiles remain insufficiently characterized. Objectives: This study assessed IL-6, IL-8, IL-11 and leptin concentrations in tumor and corresponding surgical margins. Also, we aimed to determine …

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EndoCompass Project: Research Roadmap for Thyroid Endocrinology

Agnieszka Piekiełko‐Witkowska, Rossella Elisei, Juliane Léger, Běla Bendlová et autres

BACKGROUND: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national …

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Germline Mutations in DNA Repair Genes in Patients with Pancreatic Neuroendocrine Neoplasms: Diagnostic and Therapeutic Implications

Beata Jurecka‐Lubieniecka, Małgorzata Roś-Mazurczyk, Aleksandra Syguła, Alexander Jorge Cortez et autres

Pancreatic neuroendocrine neoplasms (pNENs) are the second most common type of pancreatic cancer after pancreatic ductal adenocarcinoma. Germline mutations in DNA repair genes drive several hereditary and sporadic cancers; however, their role in pNENs remains poorly defined. This pilot study aimed to …

pl, hu (code pays fourni par la source)

EndoCompass project: research roadmap for thyroid endocrinology

Agnieszka Piekiełko‐Witkowska, Rossella Elisei, Juliane Léger, Běla Bendlová et autres

BACKGROUND: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national …

pl, it, fr, cz, de, dk, se, nl, gb, be, hu, ch (code pays fourni par la source)

The phenomenon of the BRAF and TERTp mutational duet in melanoma and other cancers

Dagmara Rusinek, Aleksandra Pfeifer, Artur Zajkowicz, Karolina Tęcza et autres

The unique oncogenic duo of BRAF and TERT promoter ( TERT p) variants was demonstrated to be associated with aggressiveness and poor prognosis in several different cancer types, including melanoma and thyroid cancer. It has been shown that the coexistence of BRAF …

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MiRNA in archival serum samples derived from breast cancer patients treated with neoadjuvant chemotherapy vs freshly collected samples: Pilot study

Marcin Kubeczko, Patrycja Tudrej, Tomasz Tyszkiewicz, Aleksandra Krzywon et autres

BACKGROUND: Liquid biopsy, including miRNA profiling, is a promising approach to identify breast cancer (BC) resistance. However, the effect of long-term storage on the quality of miRNA assessment in archival serum has not been fully addressed. OBJECTIVES: We aimed to determine whether …

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Are the Common Genetic 3′UTR Variants in ADME Genes Playing a Role in Tolerance of Breast Cancer Chemotherapy?

Karolina Tęcza, Magdalena Kalinowska, Dagmara Rusinek, Artur Zajkowicz et autres

We studied the associations between 3′UTR genetic variants in ADME genes, clinical factors, and the risk of breast cancer chemotherapy toxicity. Those variants and factors were tested in relation to seven symptoms belonging to myelotoxicity (anemia, leukopenia, neutropenia), gastrointestinal side effects (vomiting, …

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The Role of Single Nucleotide Polymorphisms in MicroRNA Genes in Head and Neck Squamous Cell Carcinomas: Susceptibility and Prognosis

Elżbieta Szmida, Dorota Butkiewicz, Paweł Karpiński, Tomasz Rutkowski et autres

BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent cancers worldwide. The identification of molecular alterations adding to the individual risk of HNSCC development and progression is one of the most important challenges in studies on cancer …

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Polish diagnostic and therapeutic recommendations for adrenocortical carcinoma

Daria Handkiewicz-Junak, Marek Dedecjus, Urszula Ambroziak, Marcin Barczyński et autres

Advances in the diagnosis and treatment of adrenocortical carcinoma (ACC), along with the development of new therapeutic and diagnostic methods, have prompted a team of experts to formulate the first Polish guidelines for managing ACC. This article presents the diagnostic and therapeutic …

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175 Induction radiochemotherapy with low dose fractionation XRT in patients with advanced HNSCC.

Urszula Kacorzyk, Marek Kentnowski, Katarzyna Drosik‐Rutowicz, Dorota Słonina et autres