Alfred W. Legasse

Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques

Helen L. Wu, Kathleen Busman‐Sahay, Whitney C. Weber, Courtney M. Waytashek et autres

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A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques

Margo A. Brinton, Minsha Manoharan, Heather A. Vatter, Eric Donaldson et autres

Simian hemorrhagic fever virus is an arterivirus that naturally infects species of African nonhuman primates causing acute or persistent asymptomatic infections. Although it was previously estimated that 1% of baboons are SHFV-positive, more than 10% of wild-caught and captive-bred baboons tested were …

A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques

Scott W. Wong, Shannon L. Planer, Ralph Steven Baric, Eric Donaldson et autres

Simian hemorrhagic fever virus is an arterivirus that naturally infects species of African nonhuman primates causing acute or persistent asymptomatic infections. Although it was previously estimated that 1% of baboons are SHFV-positive, more than 10% of wild-caught and captive-bred baboons tested were …

Terumo spectra optia leukapheresis of cynomolgus macaques for hematopoietic stem cell and T cell collection

Helen L. Wu, Justin Russell Greene, Tonya Swanson, Christine Shriver‐Munsch et autres

Abstract Macaques are physiologically relevant animal models of human immunology and infectious disease that have provided key insights and advanced clinical treatment in transplantation, vaccinology, and HIV/AIDS. However, the small size of macaques is a stumbling block for studies requiring large numbers …

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Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques

Marvin M. Festag, Tonya Swanson, Alex Klug, Thomas Jacob et autres

Hepatitis B virus (HBV) is a major global health concern, and the development of curative therapeutics is urgently needed. Such efforts are impeded by the lack of a physiologically relevant, pre-clinical animal model of HBV infection. Here, we report that expression of …

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Viral opportunistic infections in Mauritian cynomolgus macaques undergoing allogeneic stem cell transplantation mirror human transplant infectious disease complications

Helen L. Wu, Whitney C. Weber, Christine Shriver‐Munsch, Tonya Swanson et autres

Allogeneic hematopoietic stem cell transplantation (HSCT) and xenotransplantation are accompanied by viral reactivations and virus-associated complications resulting from immune deficiency. Here, in a Mauritian cynomolgus macaque model of fully MHC-matched allogeneic HSCT, we report reactivations of cynomolgus polyomavirus, lymphocryptovirus, and cytomegalovirus, macaque …

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Donor T cell chimerism correlates with viral reservoir clearance following allogeneic stem cell transplantation in fully cART-suppressed Mauritian cynomolgus macaques

Helen L. Wu, Whitney C. Weber, Shaheed A. Abdulhaqq, Christine Shriver‐Munsch et autres

apoptosis) was measured.GVHD was also analyzed against the comparable transfer of human lymphocytes into NSG mice.

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A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge

Scott G. Hansen, Emily E. Marshall, Daniel Malouli, Abigail B. Ventura et autres

challenge, providing control and progressive clearance of SIV infection in 59% of vaccinated RMs. Moreover, among 12 ΔRh110 RhCMV/SIV-vaccinated RMs that controlled and progressively cleared an initial SIV challenge, 9 were able to stringently control a second SIV challenge ~3 years after …

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Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity

Emily E. Marshall, Daniel Malouli, Scott G. Hansen, Roxanne M. Gilbride et autres

phenotype, epitope targeting, and durability. Thus, pp71 deletion preserves CMV vector immunogenicity while stringently limiting vector spread, making pp71 deletion an attractive attenuation strategy for HCMV vectors.

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Vaccine-Mediated Inhibition of the Transporter Associated with Antigen Processing Is Insufficient To Induce Major Histocompatibility Complex E-Restricted CD8+T Cells in Nonhuman Primates

Shaheed A. Abdulhaqq, Helen L. Wu, John B. Schell, Katherine B. Hammond et autres

Due to the near monomorphic nature of MHC-E in the human population and inability of many pathogens to inhibit MHC-E-mediated peptide presentation, MHC-E-restricted T cells have become an attractive vaccine target. However, little is known concerning how these cells are induced. Understanding …

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Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound

Afam A. Okoye, Scott G. Hansen, Mukta Vaidya, Yoshinori Fukazawa et autres

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Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine

Scott G. Hansen, Daniel E. Zak, Guangwu Xu, Julia C. Ford et autres

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