Petros C. Karakousis

The Phosphate-Specific Transport System Gene pstA1 Contributes to Rifampin Tolerance in Mycobacterium tuberculosis

Carina Danchik, Anoushka Chinmayi, G. Lee, Subramanian Mahadevan et autres

BACKGROUND: Tuberculosis (TB) caused an estimated 10.7 million new cases and 1.23 million deaths in 2024. Antibiotic tolerance, the ability of bacteria to survive bactericidal antibiotics without genetic resistance mutations, contributes to prolonged treatment. Targeting tolerance mechanisms could promote accelerated clearance of …

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A copper uptake ABC transport system is essential for Mycobacterium tuberculosis virulence

Zhihong Xu, Huang Tang, Meiyi Yan, Haifeng Li et autres

Mycobacterium tuberculosis (Mtb) is a facultative intracellular pathogen that thrives primarily inside the phagosome of macrophages. A key Mtb survival strategy is to exploit and manipulate metal cation trafficking inside macrophages. Copper plays dual roles in host–pathogen interactions, i.e. as a bactericidal …

A copper uptake ABC transport system is essential for Mycobacterium tuberculosis virulence

Zhihong Xu, Huang Tang, Meiyi Yan, Haifeng Li et autres

Mycobacterium tuberculosis (Mtb) is a facultative intracellular pathogen that thrives primarily inside the phagosome of macrophages. A key Mtb survival strategy is to exploit and manipulate metal cation trafficking inside macrophages. Copper plays dual roles in host–pathogen interactions, i.e. as a bactericidal …

A copper uptake ABC transport system is essential for Mycobacterium tuberculosis virulence

Zhihong Xu, Huang Tang, Meiyi Yan, Haifeng Li et autres

Mycobacterium tuberculosis (Mtb) is a facultative intracellular pathogen that thrives primarily inside the phagosome of macrophages. A key Mtb survival strategy is to exploit and manipulate metal cation trafficking inside macrophages. Copper plays dual roles in host-pathogen interactions, i.e., as a bactericidal …

cn, hr, us (code pays fourni par la source)

Immunotherapy targeting drug-tolerant Mycobacterium tuberculosis persisters accelerates tuberculosis cure in preclinical models

Styliani Karanika, Tianyin Wang, Addis Yilma, Jennie Ruelas Castillo et autres

Mycobacterium tuberculosis remains a global health crisis, ranking among the deadliest infectious diseases worldwide. In response to the WHO's call for therapeutic vaccines to complement antibiotic regimens and reduce tuberculosis (TB) treatment duration, we developed an intranasal DNA vaccine fusing the M. …

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Acetylsalicylic Acid and Ibuprofen as Adjunctive Therapy for Tuberculosis

Lilibeth Arias, Ziyaad Waja, Nestani Tukvadze, Tumelo Moloantoa et autres

ABSTRACT Background As novel strategies are needed to improve tuberculosis (TB) outcomes and shorten treatment; we evaluated whether host-directed therapy with non-steroidal anti-inflammatory drugs (NSAIDs) could enhance treatment response when added to standard therapy. Methods We conducted a phase 2b, double-blind, placebo-controlled, …

es, Afrique du Sud, ch, ge, gb, no, us (code pays fourni par la source)

Discovery of highly potent α-keto ester-based peptidomimetic inhibitors of the Hip1 protease for the treatment of Mycobacterium tuberculosis

Nicholas C. Schumann, Farah Shamma, Cory L. Brooks, Sean J. Johnson et autres

Mycobacterium tuberculosis (Mtb), the bacterium responsible for tuberculosis, is the leading cause of death due to a single infectious agent. Given the alarming increase in drug-resistant cases, therapeutic agents targeting novel Mtb drug targets are urgently needed. Hip1, a serine protease required …

au, us (code pays fourni par la source)

The Phosphate-Specific Transport System Gene pstA1 Contributes to Rifampin Tolerance in Mycobacterium tuberculosis

Carina Danchik, G. V. Anoushka Chinmayi, Gi Yong Lee, Joel S. Bader et autres

Abstract Tuberculosis (TB) caused an estimated 10.8 million new cases and 1.25 million deaths in 2023. Antibiotic tolerance, the ability of bacteria to survive exposure to bactericidal antibiotics without genetic resistance mutations, contributes to the need for prolonged treatment. Targeting antibiotic tolerance …

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Cholesterol efflux in HIV-associated atherosclerosis: mechanisms and targets

Emily Ming‐Chieh Lu, Vignesh Chidambaram, Amudha Kumar, Hannah G Cotto Aparicio et autres

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MIP3α-RelMtb intranasal DNA vaccination induces reactive T-cell infiltration into the lungs of mice and macaques

James T. Gordy, Jean J. Zheng, Amanda Maxwell, Rowan E. Bates et autres

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MIP-3α-antigen fusion DNA vaccine enhances sex differences in tuberculosis model and alters dendritic cell activity early post vaccination

James T. Gordy, Rowan E. Bates, Elizabeth M. Glass, Jacob Meza et autres

Abstract Tuberculosis disease (TB) caused by Mycobacterium tuberculosis (Mtb) bacteria remains a major cause of global morbidity and mortality. Efforts to control TB are hampered by the lengthy and cumbersome treatment required to eradicate the Mtb infection. Bacterial persistence during exposure to …

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SARS-CoV-2 induces neutrophil degranulation and differentiation into myeloid-derived suppressor cells associated with severe COVID-19

Leon L. Hsieh, Elizabeth A. Thompson, Nirvani P. Jairam, Katerina Roznik et autres

Severe COVID-19 presents with a distinct immunological profile, characterized by elevated neutrophil and reduced lymphocyte counts, seen commonly in fungal and bacterial infections. This study demonstrates that patients hospitalized with COVID-19 show evidence of neutrophil degranulation and have increased expression of neutrophil …

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